The enantiomer-specific structure of local anaesthetics has large impact on the pharmacokinetic process of these drugs, including absorption, protein-binding ratio, metabolism, and so on.

药物对映体结构特异性对局麻药药代动力学的各个过程都有着很大影响，包括药物的吸收、蛋白结合率、代谢等。

youdao

Information technology has had a significant impact on the productivity of large enterprises.

信息科技已经对大型企业的生产力产生了重大的影响。

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Building a kernel that is capable of protecting against itself is difficult, and usually has a large negative impact on performance.

构建一个具有防护来自自身攻击能力的内核很困难，并且通常这会对性能产生很大的负面影响。

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Paper,for example,has little impact on the environment as it is being used, but requires large amounts of energy and resources for its production."

VOA: standard.2009.03.30

"The fact that unemployment has remained so high does suggest that the stimulus has not had as large an impact as the administration claims."

VOA: standard.2010.06.18

In this nascent age of Social TV metrics, a philosophy about what actually matters in the space has a large impact on results.

FORBES: SpongeBob SquarePants vs. The X Factor: A Social TV Throwdown In Infographics

The festival has had another large impact, as well.

FORBES: At The South Beach Wine & Food Festival, Gluttony For The Greater Good

Local agencies are still assessing the damage, but the large volunteer response has already made an impact.

CNN: Cleanup begins after tornado outbreaks