The enantiomer-specific structure of local anaesthetics has large impact on the pharmacokinetic process of these drugs, including absorption, protein-binding ratio, metabolism, and so on.
药物对映体结构特异性对局麻药药代动力学的各个过程都有着很大影响，包括药物的吸收、蛋白结合率、代谢等。
Information technology has had a significant impact on the productivity of large enterprises.
信息科技已经对大型企业的生产力产生了重大的影响。
Building a kernel that is capable of protecting against itself is difficult, and usually has a large negative impact on performance.
构建一个具有防护来自自身攻击能力的内核很困难，并且通常这会对性能产生很大的负面影响。
This has a significant impact on the time it takes to ingest a large amount of MIML data.
这对于摄取大量MIML数据所花的时间有很大的影响。
Even in countries where the epidemic has a very high impact, such as Swaziland and South Africa, a large proportion of the population do not believe they are at risk.
即使在艾滋病流行具有很大影响的国家，例如斯威士兰和南非，很大部分的人不认为他们有危险。
Once you have that large display area, you'll never go back, because it has a direct impact on productivity.
只要你用了大屏幕，你就回不去了，因为它直接影响到生产率。
It has been criticized for the environmental impact it has had on the local flora and fauna but sustains large communities of people spread over three states.
它因对当地的动植物群有影响而遭受批评，但却满足着三个州的社区需求。
Toward that end, the FreeBSD Foundation has started to engage with large current and potential users of OpenSource software to understand their use models and how the GPLv3 might impact them.
为此，FreeBSD基金会已经开始与大型的开源软件用户和潜在用户接洽，帮助他们了解他们所采用的使用模式，以及GPLv3可能带来的不利影响。
Similarly, the results in the charts emphasize that the amount of memory available on the system has a large impact upon Notes.
类似地，图表中的结果还指出系统的可用内存量对Notes有巨大的影响。
The NavmeshQueryFilter is a seemingly minor class, but it has a large impact on navigation.
是一个看起来很小的类，但是它对导航的影响很大。
"I am always skeptical when I hear the claim that a particular food or food component has a very large impact on health," she says.
“当我听到有关某种特别食物或事物成分对健康有很大作用的声称时，我总是持怀疑态度。”她补充道。
Since you joined the Gates Foundation, or indeed at any other point in your career, has your thinking about how to create large-scale impact changed?
自您加入盖茨基金会，或者在您的职业生涯的某些阶段，您思考过如何创建大规模的改变吗？
The large detrimental impact that smoking already has on public health has the potential to become even greater as the population worldwide ages and dementia prevalence increases.
随着全球范围内人口的老化和痴呆流行的增加，吸烟对公共健康已经产生的巨大有害作用有变得更加严重的可能。
Core of large roller cold upsetting die made of ld steel has more ideal hardness, strength, anti wear capacity and impact toughness.
采用LD钢制造大型滚子冷镦模具的模芯，具有较理想的硬度、强度、耐磨性和冲击韧性。
This corresponds with the large cultural differences between the world's two largest economies, which has an impact on how crowdfinancing is conducted.
这个现象与中美这两个全球最大的经济体的巨大文化差异是一致的，这种文化差异也影响了众筹的实践方式。
The rate of extrusion has a large impact on the quality of the product and should be adjusted accordingly.
挤压比率大大的影响着产品质量，因而需要相应的调整。
In some cases, figuring out what constitutes the 20% that has such a large impact is easy.
在某些情况下，搞清楚什么构成的20%有如此大的影响是容易的。
It is showed that long-range dependence has a quite different impact on queueing performance from that of short-rang dependence, especially on the condition of large buffer size.
研究表明长程相关和短程相关对于排队系统性能具有非常不同的影响，尤其是在缓存较大的情况下。
Along with China's interring the large-scale consumption time, consumerism has exerted increasingly profound impact on people's value concept and life style.
随着中国开始进入大规模消费消费时代，消费主义对人们的价值观念和生活方式产生了日益深刻的影响。
Immediate and significant: "This troubled asset relief program has to be properly designed for immediate implementation and be sufficiently large to have maximum impact and restore market confidence."
直接和重大的：“这个多灾多难的资产救济计划已经得到适当的设计，并立即执行应当足够大，以产生最大的影响和恢复市场信心。”
Large power transformer is one of the most important and expensive equipment in the power system, its operation statements has a direct impact on the power system security.
大型电力变压器是电力系统最重要和最昂贵的设备之一，其运行状态直接影响系统的安全性。
The migration of youth from rural area has a large impact on living arrangement of elderly.
农村年轻劳动力外流对老年人的居住安排产生了很大影响。
While some authors have attributed large productivity improvements and substantial consumer benefits to IT, others report that IT has not had any bottom line impact on business profitability.
一些理论学家将生产力的改善和充实的消费者的受益归功于IT技术，另一些则认为IT技术对企业的收益性没有任何影响结果。
The utility model has the advantages of low deposition temperature, no high-energy ion impact damage, large deposition area, simple operation, microcomputer programmed control, energy saving, etc.
具有淀积温度低，没有高能离子撞击损伤，淀积面积大，操作简单，微机程序控制，节约能源等优点。
Survey results indicate that facade design has a large impact on the occupants' perceived control over and satisfaction with their environments.
调查结果表明，立面设计对居住者的控制感以及他们对环境的满意程度有很大的影响。
Shenzhen has a large number, the impact of the country and the world of design elite, Chen Shaohua, Han-ying, Zhang Dali, and other graphic designers in the domestic design industry has long known.
深圳拥有为数众多、影响全国乃至世界的设计精英，陈绍华、韩家英、张达利等平面设计师在国内设计界久负盛名。
Shenzhen has a large number, the impact of the country and the world of design elite, Chen Shaohua, Han-ying, Zhang Dali, and other graphic designers in the domestic design industry has long known.
深圳拥有为数众多、影响全国乃至世界的设计精英，陈绍华、韩家英、张达利等平面设计师在国内设计界久负盛名。
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