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first-pass effect

  • 首过效应

网络释义专业释义英英释义

  首关效应

first-pass effect首关效应:是指某些药物首次通过肠壁或经门静脉进入肝脏时被其中的酶所代谢致使进入体循环药量减少的一种现象。

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  首过效应

... 手性药物 chiral drug 首过效应 first-pass effect 受体 receptor ...

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短语

first pass effect 首过效应 ; 效应 ; 首关效应 ; 首渡效应

first pass effect of hepar 肝首过效应

liver first pass effect 肝首过效应

pseudo-first-pass effect 伪首过效应

the first-pass effect 首过效应中的某些

intestinal first pass effect 肠道首过效应

first-pass s effect 首过效应

 更多收起网络短语
  • 首过效应 - 引用次数：15

    To avoid the extensive first-pass effect, intranasal administration is chose after reconstitution.

    加水重建后，选择鼻粘膜给药途径以避免药物的首过效应。

    参考来源 - 鼻粘膜给药尼莫地平冷冻干燥脂质体的研究
    首过作用 - 引用次数：2

    ODT has some advantages like quick absorption, high bioavailability, taking convenience, less residual in intestine. Furthermore, it can also avoid the first-pass effect of liver.

    与普通制剂相比,口腔崩解片具有吸收快、生物利用度高、服用方便、肠道残留量少、部分避免肝脏首过作用、患者的顺应性好等优点。

    参考来源 - 氟比洛芬口腔崩解片的研究

·2,447,543篇论文数据，部分数据来源于NoteExpress

First pass effect

  • abstract: The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall.

以上来源于: WordNet

双语例句

  • Objective: To explore the first-pass effect in Small intestine.

    目的：探讨小肠在首过效应中的作用。

    youdao

  • ConclusionThe metabolism of DBDCT in rat liver microsomes was faster, suggesting that the liver first-pass effect of the drug may be stronger.

    结论DBDCT在大鼠肝微粒体中代谢较快，提示该药可能肝首过效应较强。

    youdao

  • The objective of this study was to develop a good absorbed and stable preparation that can avoid the strong first-pass effect of nimodipine (NMD).

    本文旨在寻找制备一个吸收良好、稳定性好、可避免尼莫地平强的首过效应的制剂。

    youdao

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