We are eager to explore the underlying transcriptional and epigenetic mechanisms of somatic cell reprogramming.

我们将研究在体细胞重编程过程中的转录调控和表观遗传调控机制。

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In the present paper we review the role and molecular mechanism of transcription factors, epigenetic regulation and cell signaling in cell reprogramming.

本文主要从转录因子、表观遗传和信号转导等角度，介绍了细胞重编程分子机制研究方面的进展和未来的方向。

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Researching the mechanism of action of these transcription factors is beneficial to the further explanation of the molecular mechanism of the cell reprogramming.

对这些转录因子作用机制的了解，有助于细胞重编程分子机制的进一步阐明。

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Dr Keisuke Kaji, a stem cell researcher at the Medical Research Council Centre for Regenerative Medicine in Edinburgh said the technique was a "great advance" in cell reprogramming technology.

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The literature on similarities and differences between ES cells and iPS cells, he said, is quite controversial and scientists still do not know whether differences between different iPS cell lines are just due to genetic differences between the adult cell lines that were used for reprogramming or whether genetic changes occurred during reprogramming.

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It takes about four weeks for a skin cell to be "primed" for reprogramming, and then it takes an additional three to four weeks for iPS colonies to grow, according to Dr. Joseph Wu, study co-author and assistant professor of cardiology and radiology at Stanford's School of Medicine.

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