亚硝基胍,熔点为118℃,结晶体,溶于水,易燃、有毒、有致癌可能性、有刺激性。
离体实验是采用永生化的人胃粘膜上皮细胞系GES-1细胞被N-甲基-N-硝基-N-亚硝基胍(MNNG)或幽门螺杆菌(HP)培养滤液进一步转化后的细胞(MC细胞)作为胃癌前病变细胞的体外研究模型。
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...有诱变效果,尤其是亚硝基胍诱变效果较好(表1),在试验条件下能在死亡率较小的条件下得到较大的突变率。作者最终采用亚硝基胍(NTG)、硫酸二乙酯(DES)作为化学诱变剂。
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文章摘要 关键词 生米卡链霉菌;紫外线;亚硝基胍;前体;发酵[gap=1173]Key words Streptomyces mycarofaciens;UV;nitrosoguanidine(NTG);precursor;fermentation process
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Moreover, after we had tried to mutagenize the cells with N-methyl-N`-nitrosoguanidine (MNNG), some transformed cells had some morphological changes and grew in multilayer. In the meantime, many foci turned up.
另外,还进行了以N-甲基-N′-亚硝基胍(MNNG)对原代细胞进行诱变的尝试,发现诱变后有的细胞呈现出转化细胞的形态,并形成了转化灶。
参考来源 - 中国对虾淋巴组织的长期原代培养和化学诱变初探 The Long·2,447,543篇论文数据,部分数据来源于NoteExpress
目的:分析甲基硝基亚硝基胍(MNNG)诱导的共表达蛋白的编码基因启动子区的转录因子结合部位。
AIM: to find out common transcription factor binding sites in the promoter regions of the encoding genes of the co-expressive proteins induced by N-methyl-N '-nitro-n - nitrosoguanidine (MNNG).
目的:了解人REV3基因对化学致癌物N-甲基- N’-硝基- N-亚硝基胍(MNNG)诱发转录上调的机制。
Objective: To understand the up retulatory mechanism of human REV3 gene induced by the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
用固体亚硝基胍诱变该菌株,在选择培养基上筛选到盐敏感突变株和盐依赖突变株。 并初步研究了这些突变菌株的生长特性。
Salt tolerant mutant and salt dependent mutants were screened on selective medium by using solid NTG to mutagenize B5. Some characteristics of these mutants have been studied.
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