胃粘膜病变 建立胃癌前病变动物模型,一般以甲基硝基亚硝基胍(MNNG)作为工具药。以往常单用低浓度的MNNG自由饮用,但诱发率相对较低,且多为胃粘膜异型增生,少有肠化生;目前常针对不同的研究目的...
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目的:分析甲基硝基亚硝基胍(MNNG)诱导的共表达蛋白的编码基因启动子区的转录因子结合部位。
AIM: to find out common transcription factor binding sites in the promoter regions of the encoding genes of the co-expressive proteins induced by N-methyl-N '-nitro-n - nitrosoguanidine (MNNG).
目的:了解人REV3基因对化学致癌物N-甲基- N’-硝基- N-亚硝基胍(MNNG)诱发转录上调的机制。
Objective: To understand the up retulatory mechanism of human REV3 gene induced by the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
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