This is a big issue ; we need more time to think about it.

这是个重大问题，我们需要花较多的时间考虑。

《牛津词典》

The new ultra-low emission zone (Ulez) is likely to be a big issue in next year's mayoral election.

“超低排放新区（Ulez）”很可能是明年伦敦市长选举的重大议题。

youdao

When you want to study ancient human and Neanderthal remains, there's a big issue of contamination with contemporary human DNA.

当你想要研究古人类和尼安德特人的遗骸，一个大问题是当代人类的 DNA 受到的污染。

youdao

And that's become a big issue. Not necessarily because of the location, but because of the security measures that have been taken.

VOA: standard.2010.02.17

There's never been a successful third-party political culture take hold in this country without one really big issue to drive it.

美国就从没有过,第三政党真正成功执政的时候,因为缺乏一个真正重大的议题来支持它

耶鲁公开课 - 美国内战与重建课程节选

But whenever we've had a reform era there's been a big issue, or two or three or four.

但每当我们有一个改革的时代,都会存在一个,两个,三个或者四个大问题

耶鲁公开课 - 美国内战与重建课程节选

"People being able to hack into the car is a big issue, " says Bergquist.

BBC: 'Every new car' connected to web by 2014

And so the water is over-allocated, and that's a big issue in the West.

NPR: Can Climate Change Explain Odd Weather?

Another big issue: Land is plentiful in the U.S., and therefore landfills are cheap.

FORBES: How To Burn Trash For Power