"You want to hold a review and you want to exclude the one big issue which should be right at the heart of that review."

VOA: standard.2010.04.30

There's never been a successful third-party political culture take hold in this country without one really big issue to drive it.

美国就从没有过,第三政党真正成功执政的时候,因为缺乏一个真正重大的议题来支持它

耶鲁公开课 - 美国内战与重建课程节选

But whenever we've had a reform era there's been a big issue, or two or three or four.

但每当我们有一个改革的时代,都会存在一个,两个,三个或者四个大问题

耶鲁公开课 - 美国内战与重建课程节选

"Because if you are talking about a teaching force of over 35,000 and you are saying 40 percent of those ones are untrained and unqualified, then it is a big issue."

VOA: standard.2010.02.25

That's a big issue. You can fix one thing, you break something else.

你可以解决一个问题，但你破坏了其它的程序。

麻省理工公开课 - 计算机科学及编程导论课程节选

Health care is a big issue for AARP members.

VOA: standard.2009.07.28

And so the big issue is -- this is what you must never do, but this is what you got to do if your phalanx is broken.

所以现在的大问题是,这也许是你在战场上永远不能做的事,但你在方阵被打散时不得不这么干

耶鲁公开课 - 古希腊历史简介课程节选

"Absolutely I think that under different circumstances they could have turned it into a big issue in their relationship, and we could have seen mutual accusation and a lot of hysteria on both sides."

VOA: standard.2010.07.09

The lack of housing is also a big issue,partly because of the years of conflict, which have not given us a clear idea of how many homes have actually been destroyed in Afghanistan or badly damaged.

VOA: standard.2009.09.13

"Obviously there is a bit of a spread between those two figures and it suggests the possibility of some political problems for the president if he should not take the military recommendation and that difference gets to be a big issue,".

VOA: standard.2009.10.09

But for people who have a difficult time controlling their movements, this little navigational issue can be a really big problem.

VOA: special.2011.04.18

"That's really the biggest issue. When there is really a big sudden fire, the time to evacuate is extremely limited and extremely dangerous.

VOA: standard.2009.06.24

U.S.officials hope it can be convened before key big-power discussions of the Iranian nuclear issue begin in New York during the third week of this month, on the sidelines of the U.N.General Assembly session.

VOA: standard.2009.09.11