The investigations of statins show that the drugs may have an anti-fibrotic effect by the inhibition of MMPs, intervention of fibroblast proliferation and collagenic synthesis,the accommodation of ECM deposition.
各种研究显示他汀类药物可通过抑制基质金属蛋白酶、干预成纤维细胞增殖、胶原合成、参与调节细胞外基质的降解，可能具有抗纤维化作用，但目前直接进行体内观察其抗肺纤维化作用的研究并不多。
参考来源 - 阿托伐他汀对实验性肺纤维化的保护及其MMP·2,447,543篇论文数据，部分数据来源于NoteExpress
Would you please give us a brief introduction on the possible strategies to target HSCs using anti-fibrotic agents?
请您给我们介绍一下抗肝纤维化药物对于肝星状细胞的可能的作用机制？
The theme at this point is that if you control the underlying disease you are effectively giving an anti-fibrotic drug.
需要指出的是如果能够控制潜在疾病，实际上就是给予了最有效的抗纤维化药物。
Objective To study the anti-fibrotic and anti-injurious activities of TCM and autologous bone marrow stem cells transplantation.
研究中药归元方与自体骨髓干细胞移植对急慢性肝损伤的治疗作用。
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