Would you please give us a brief introduction on the possible strategies to target HSCs using anti-fibrotic agents?
请您给我们介绍一下抗肝纤维化药物对于肝星状细胞的可能的作用机制？
The theme at this point is that if you control the underlying disease you are effectively giving an anti-fibrotic drug.
需要指出的是如果能够控制潜在疾病，实际上就是给予了最有效的抗纤维化药物。
Objective To study the anti-fibrotic and anti-injurious activities of TCM and autologous bone marrow stem cells transplantation.
研究中药归元方与自体骨髓干细胞移植对急慢性肝损伤的治疗作用。
Hepatology Digest: you mentioned that these cells can control inflammation. Do you think this has any potential as an anti-fibrotic therapy?
《国际肝病》：您提到了这些细胞可以控制炎症，您认为它们具有潜在的抗纤维作用吗？
Hepatology Digest: Several preclinical studies showed that experimental anti-fibrotic drugs are not effective in animal models with liver fibrosis.
《国际肝病》：几种临床前期的试验研究表明，进行试验的抗肝纤维化药物对于肝纤维化动物模型并不是很有效。
Hepatology Digest: you have just presented the latest developments in novel anti-fibrotic targets and agents. Could you introduce your key message to our readers?
《国际肝病》：您刚才介绍了新型抗肝纤维化靶点和药物的的最新进展。你能否再给我们的读者介绍一下您演讲的要点？
AIM: To activate hepatic stellate cells (HSC) in vitro in precision-cut liver slices (PCLS) stimulated by acetaldehyde for studying and screening anti-fibrotic drugs.
目的：在精密肝切片中利用乙醛激活肝星状细胞，建立一种星状细胞激活的体外模型，为研究和筛选阻抑肝纤维化发生的药物奠定基础。
The next step, of course, is to develop drugs that target only the fibrotic response, or additionally the fibrotic response, and still continue to yield an anti-fibrotic benefit.
下一步，当然是要开发针对纤维化应答的药物，或额外的纤维化应答，仍可继续产生抗纤维化效果。
Following a brief introduction of relaxin family members, receptors and related signalling pathways, we review effects of relaxin on cardiovascular system, particularly, its anti-fibrotic action.
简要介绍松弛素家族的成员、受体及其相关信号通路，重点回顾松弛素在心血管系统中的作用特别是其抗纤维化作用。
Following a brief introduction of relaxin family members, receptors and related signalling pathways, we review effects of relaxin on cardiovascular system, particularly, its anti-fibrotic action.
简要介绍松弛素家族的成员、受体及其相关信号通路，重点回顾松弛素在心血管系统中的作用特别是其抗纤维化作用。
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