It has become a very significant issue regarding how to accurately, comprehensively and quickly find the desired information within a narrow field of knowledge from the huge number of information.

如何快速、准确、全面地从浩瀚的信息资源中寻找到所要的狭小领域内的相关信息内容，已经成为了一项十分有意义的课题。

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This is a very important issue, given the very significant public health implications of tobacco control for reduction of chronic diseases in future.

鉴于烟草控制对今后减少慢性病极为显著的公共卫生影响，这是一个很重要的问题。

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"I'm sure some will take issue with their conclusions," he says, "but this is a very significant study."

他说：“我肯定有些人会反对她们的结论，但这是一项非常重要的研究。”

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We feel that this lawsuit is not a very significant issue for the company.

FORBES: Dish's Hopper Threatens To Shake Up Pay-TV Industry

In its letter, the Presbyterian Church said it was "not merely an issue of conscience for Christian people and churches, but a very significant one for the whole of society".

BBC: A couple handing hands