This decision signified a radical change in their policies.

这个决定表明了他们的政策发生了根本的变化。

《牛津词典》

Shifting eating habits, including a sharp drop in consumption of sparkling drinks, have forced a radical change in the industry.

饮食习惯的改变，包括汽水消费量的大幅下降，迫使该行业发生了根本性的变化。

youdao

Such a radical change would involve difficult negotiations with local stations.

这样根本性的变革将可能涉及同地方电视台一系列困难的谈判。

youdao

"Instead of collecting data today to plan for a campaign next year, changing from that to collecting data today to plan for what we do tomorrow, that is a pretty radical change."

VOA: special.2010.05.03

And, if not, how does it adapt to such a radical change in circumstances?

BBC: How do book towns survive in the age of the e-reader?

Intel 's new Core chips are a hit for the company--and a radical change.

FORBES: Hard Core

Time will tell if the argument for what seems a radical change can be won.

BBC: Has London's congestion charge worked?