为了进一步提高外源蛋白质的分泌表达，对信号肽序列进行了研究。
For further improving the secretion expression of heterogeneous proteins, in this research, the signal sequences were studied.
结论构建了人瘦素的哺乳动物细胞表达载体，并成功地在COS 7细胞中获得重组人瘦素的分泌表达。
Conclusion Cloning and expression recombinants of human leptin are obtained and secretive recombinant human leptin is successfully expressed in COS-7 cells.
紫外线作用于成纤维细胞，引起细胞因子分泌及基因表达的改变，不仅能造成真皮层的损伤，还可被用来治疗某些疾病，如局限性硬皮病。
Ultraviolet not only causes dermal damages by changing cytokine secretion and gene expression of human skin fibroblasts, but also is used to treat some diseases such as localized scleroderma.
电针可以增加大鼠脑缺血区皮层ngf的分泌和表达时程，这可能是其保护缺血性脑损伤的机制之一。
Ea can increase the secretion and expression period of NGF in rats ischemic cortex, and this may be one of its protective mechanisms for ischemic cerebral damage.
研究表明，组蛋白的乙酰化与去乙酰化状态，可作用于T、B细胞的发育、分化、成熟、分泌及表面因子的表达等多个方面。
Studies had shown that acetylation and deacetylation of histone are of certain value on t, B cell's development, differentiation, maturation, secretion and surface factor's expression etc.
结论：GLP鄄1可促进大鼠胰岛细胞胰岛素基因的表达和蛋白的分泌，对大鼠胰岛细胞亦有明显的促增殖作用。
Conclusion: GLP-1 can not only increase the insulin gene expression and insulin secretion, but also stimulate the proliferation of islet cells.
醛固酮合酶(CYP11B2)是醛固酮生物合成最后一步的催化酶。醛固酮的分泌主要由醛固酮合酶的表达水平来调节。
Aldosterone secretion is regulated largely at the level of expression of the final enzyme required for its biosynthesis, aldosterone synthase (CYP11B2).
这种靶向性的策略包括目的基因对肿瘤细胞的靶向转移，目的基因在肿瘤细胞中的特异表达，以及基因修饰细胞分泌的肿瘤靶向治疗分子。
This can be achieved by tumor targeted gene transfer or tumor specific gene expression, as well as secretion of tumor targeted therapeutic molecules by autologous normal cells.
瘤周正常垂体组织和垂体腺瘤组织中与垂体激素分泌及能量代谢有关的一些基因表达水平较高。
The genes related to pituitary hormone secretion and energy metabolism were highly expressed in the two kinds of tissues.
生长抑素（SS）通过抑制垂体生长激素的分泌而影响机体的生长性能，SS同时也能抑制钙蛋白酶的表达和活性。
Somatostatin (SS) is the major inhibitory factor for growth hormone secretion and has also been reported to attenuate the expression and activity of calpains.
目的探讨中国儿童正常T淋巴细胞表达和分泌的活性调节蛋白(RANTES)基因启动子- 2 8位基因多态性对儿童过敏性哮喘的影响。
Objective To study the effect of regulated upon activation, normal t cell expressed and secreted (RANTES) -28 polymorphism on allergic asthma in Chinese children.
了解不同发育、生长时期和不同生理、病理条件下及不同类型细胞分泌蛋白表达的特点对认识生命过程具有重要意义。
The understanding of the secretory protein expression characteristics of different growth period and different physiological or pathological conditions is of great significance.
枯草芽孢杆菌是继大肠杆菌之后又一广泛使用的表达系统，它没有致病性，只具有单层细胞外膜，并且能直接将许多蛋白分泌到培养基中。
As another widely used expression system following E. coli, Bacillus subtilis is not pathogenic with single-cell membrane and secreted proteins to medium directly.
MUC19在变应性鼻炎中的表达较鼻息肉及正常对照组高，MUC19在变应性鼻炎的黏液中呈高水平分泌。
The expression of MUC19 in allergic rhinitis was higher than that in nasal polyps group and normal group. It indicated that the secretion of MUC19 in allergic was on high level.
结论：醛固酮抑制3t3- L1脂肪细胞内脂素的基因表达和分泌。
CONCLUSION: Aldosterone inhibits the gene expression and protein secretion of visfatin in 3t3-l1 adipocytes.
阿托伐他汀可通过脂肪组织及内皮细胞抑制炎症介质的分泌及表达。
Atorvastatin can suppress the expression and release of inflammatory mediator by adipose tissue and endothelial cells.
阿托伐他汀可抑制炎症介质的分泌及表达，具有抗炎作用。
Atrovastatin suppress expression of inflammatory mediator. It has an effect of anti-inflammation.
目的探讨高脂饮食对大鼠神经肽Y（NPY）基因表达及分泌的影响及大鼠肥胖易感性差异的机制。
Objective To explore the effect of high-fat diet on the hypothalamic neuropeptide Y(NPY)expression and the mechanisms which predispose some individuals to become obese on high-fat diet.
摘要酵母细胞表达体系具备较为完善的蛋白质翻译后修饰和分泌的机制。
Abstract: Yeast cell has a perfect system for protein post-translational modification and secretion.
营养状况及GH等内分泌因子对GHR的表达也有调节作用。
Nutrition, GH and other factors can also regulate the expression of GHR.
该培养基与商品化的无血清培养基比较，能够使细胞生长维持较长的时间，表达产物分泌量也相对较高。
In comparison with commercial SFM, it can maintain growth of CHO cell for much longer peroid and the expressing level of HBsAg is higher too.
取肺组织检测细胞浸润、粘液的过度分泌以及炎症性生物标记物的表达。
Lung tissues were examined for cell infiltration and mucus hypersecretion, and the expression of inflammatory biomarkers.
目的探讨强心通脉胶囊对充血性心力衰竭（CHF）大鼠模型血流动力学、神经内分泌及肾脏水通道蛋白-2（AQP2）基因表达的影响。
Objective To research the influence of Qiangxin Tongmai capsule on blood dynamics, neural endocine hornmone and the expression of AQP2 mRNA in kidney of rat models with congestive heart failure (CHF).
结论：稳定表达人ox40l的乳腺癌转基因细胞在体外能有效地活化t细胞，介导其增殖、分泌细胞因子及抑制T细胞活化诱导的细胞死亡。
CONCLUSION: OX40L-MDA-MB-435 cells could activate t cells in vitro, promote t cell proliferation and cytokine secretion, and suppress t cell activation-induced cell death.
免疫细胞化学染色及ELISA法检测发现，丹参酮IIA作用组肝癌细胞VEGF表达和培养液中VEGF分泌量明显减少，与未加药对照组相比差异有统计学意义（P<0.01）。
The expression of VEGF in Tanshinone IIAtreated group was significantly lower than that in control group (P<0.01). The similar result could be observed in cell culture fluid with ELISA assay.
目前认为KSHV - MCD所表达的病毒裂解蛋白参与了细胞因子调节异常、旁分泌信号传导和疾病的发生。
It is thought that viral lytic proteins expressed in KSHV-MCD contribute to cytokine dysregulation, paracrine signaling, and the pathogenesis of this disease.
目的探讨在大鼠胰腺移植急性排斥反应中调节激活正常T细胞表达和分泌因子(RANTES)的作用。
Objective To investigate the role of regulated upon activation, normal t cell expressed and secreted (RANTES) in the acute pancreatic allograft rejection in rats.
有研究证明调节活化正常T细胞表达和分泌因子（RANTES）与类风湿关节炎、干燥综合征等多种自身免疫疾病相关。
Researches have demonstrated that Regulated on Activation, Normal T cell Expressed and Secreted ( RANTES) was related to autoimmune disease, such as Rheumatoid Arthritis and Sjogren Syndrome.
目的：探讨富含半胱氨酸的分泌型酸性蛋白(SPARC)在宫颈癌中的表达变化及其与宫颈癌生物学行为的关系。
Objective: To investigate the expression of secreted protein acidic and rich in cysteine (SPARC) in cervical carcinoma and its relationship with biological behavior of cervical carcinoma.
目的：探讨富含半胱氨酸的分泌型酸性蛋白(SPARC)在宫颈癌中的表达变化及其与宫颈癌生物学行为的关系。
Objective: To investigate the expression of secreted protein acidic and rich in cysteine (SPARC) in cervical carcinoma and its relationship with biological behavior of cervical carcinoma.
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