OBJECTIVE To synthesize Ranolazine and improve the synthetic process.
目的合成雷诺嗪并进行工艺改进。
The ranolazine works by blocking what is called delayed inward sodium current.
雷诺嗪的作用机制是阻断迟发性钠离子内流。
METHODS Ranolazine was synthesized by using 2, 6-dimethylaniline and guaiacol as the starting material fellewed by 4 step reactions.
方法以2 ，6 -二甲基苯胺、愈创木酚为原料，经酰化、烃化等4步反应制得雷诺嗪。
Although several pharmacological activities of ranolazine have been described, the precise way the drug works is not fully understood.
尽管已经说明了雷诺嗪的一些药理活性，但是该药的确切作用机制仍未完全了解。
ChinaABSTRACT: Objective To explore the effect of ranolazine on the fast sodium channel current (ina) in rabbit atrial myocytes and the existence of use-dependent blockade.
目的研究雷诺嗪对兔心房肌细胞快钠电流的影响及其是否存在使用依赖性阻滞作用。
Methods: According to the methods of Chinese Pharmacopoeia, used IR, UV, HPLC, and GC to test the physicochemical property of ranolazine such as appearance, melting point, solubility, purity et al.
方法：根据中国药典的方法，采用IR、UV、HPLC、GC对雷诺嗪的外观、熔点、溶解度、纯度等理化性质进行了考察；
Methods: According to the methods of Chinese Pharmacopoeia, used IR, UV, HPLC, and GC to test the physicochemical property of ranolazine such as appearance, melting point, solubility, purity et al.
方法：根据中国药典的方法，采用IR、UV、HPLC、GC对雷诺嗪的外观、熔点、溶解度、纯度等理化性质进行了考察；
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