The protein(P53) encoded by mutant p53 gene (mtp53) not only losses these functions, but also make cell malignant transformation.
突变型p53基因的编码蛋白不但丧失上述功能，甚至出现了促使细胞癌变的作用。
The researchers write that “depletion of mutant p53 may reduce drug resistance and lead to new strategies for treating cancer in the clinic.”
科学家在论文中写到“消灭p53突变体能够降低抗药性，引出临床癌症治疗的新方法。”
Cruciferous vegetables contain compounds that preferentially destroy ineffective mutant p53 tumor suppressor proteins, but leave the good ones alone.
十字花科的蔬菜含有一类物质，能够降解由p 53突变体产生的那些效率低下的抗肿瘤蛋白，而保留高效的蛋白。
In vivo phosphorylation at Ser315 has been observed following UV-irradiation, and a Ser315Ala mutant p53 has reduced activity as a transcription factor (17).
紫外辐射后第315位丝氨酸发生在体磷酸化已被观察到，而且Ser315Ala突变的p53能够减少其作为转录因子的活性（17）。
It has been reported that mutant p53 can interact with other transcription factors and be recruited to their binding sites to modulate the expression of their target genes.
据报道，突变的p 53可以与其他转录因子相互作用，并且被招募到它们的结合位点以调节它们靶基因的表达。
This results showed that mutant P53 expression was associated with a high Ki-67 LI and high histologic grade of tumors. P53 overexpression might be a genetic marker of tumor malignancy.
结果表明，突变型P53蛋白的表达与脑肿瘤的组织类型，分化程度及细胞的增殖有关，而它的高表达又可能是肿瘤恶性表型或转移的标志之一。
AIM: to study the expression of MDM2 and mutant-type P53 proteins in primary hepatocellular carcinoma (HCC).
目的：研究MDM2和突变型P 53蛋白表达与原发性肝细胞肝癌(HCC)发生的关系。
Objective: To analyse the significance and relationship between p53 gene mutation and the expression of mutant type p53 gene protein in the laryngeal carcinomas.
目的：探讨喉癌P53基因突变与突变性P 53基因蛋白表达之间的相互关系及意义。
Objective: To analyse the significance and relationship between p53 gene mutation and the expression of mutant type p53 gene protein in the laryngeal carcinomas.
目的：探讨喉癌P53基因突变与突变性P 53基因蛋白表达之间的相互关系及意义。
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