The mutant p53 protein was detected by microwave oven treatment and ABC immunohistochemistry,its positive nuclear staining was observed in 17 out of 37 cases of gastric cancer (46%).
微波处理ABC法检测突变型P53蛋白表达,17例为阳性,阳性率为46%。
参考来源 - 胃癌P53基因突变和蛋白表达的研究·2,447,543篇论文数据,部分数据来源于NoteExpress
The protein(P53) encoded by mutant p53 gene (mtp53) not only losses these functions, but also make cell malignant transformation.
突变型p53基因的编码蛋白不但丧失上述功能,甚至出现了促使细胞癌变的作用。
The researchers write that “depletion of mutant p53 may reduce drug resistance and lead to new strategies for treating cancer in the clinic.”
科学家在论文中写到“消灭p53突变体能够降低抗药性,引出临床癌症治疗的新方法。”
Cruciferous vegetables contain compounds that preferentially destroy ineffective mutant p53 tumor suppressor proteins, but leave the good ones alone.
十字花科的蔬菜含有一类物质,能够降解由p 53突变体产生的那些效率低下的抗肿瘤蛋白,而保留高效的蛋白。
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