AIM to observe the effect of melatonin (MT) on morphine withdrawal syndromes and determine the content of NO in plasma and brain tissue in morphine dependent mice.
目的观察褪黑激素(MT)对小鼠吗啡戒断反应及血浆、脑组织中NO含量的影响。
Objective: to observe the ultrastructure and synaptic number of cerebral regions related to psychological dependence in rats with different morphine dependent time.
目的：观察不同时程吗啡依赖大鼠心理依赖相关脑区超微结构和突触数量的变化。
Method: Electrical lesions of ventral pallidum were done in 12 morphine dependent rats and the drug seeking behavior was measured by conditioned place preference paradigm.
方法··：毁损依赖大鼠腹侧苍白球，利用条件性位置偏爱实验测定术前、术后依赖大鼠对注射吗啡侧的偏爱程度，评价腹侧苍白球在药物强化效应程度中的作用。
The present study was done both in vivo by cannulating pancreatic duct of morphine dependent rats and in vitro using perfused pancreatic slices from morphine dependent rats.
本实验采用急性吗啡成瘾法，观察了吗啡成瘾大鼠在整体胰导管引流和离体胰片灌流条件下，胰腺对CCK8刺激的反应。
Conclusi on: the firing of ventral pallidal neurons is excited prominently from morphine in the morphine dependent rats. Ventral pallidum has an important role in drug reward.
结论：吗啡显著兴奋吗啡依赖大鼠腹侧苍白球神经元，腹侧苍白球在药物强化过程中起着重要作用。
Methods SD rats were divided into 6 groups: 10-days morphine dependent group and its control, 30-days morphine dependent group and its control, detoxification group and its control.
方法将SD大鼠分为6组：吗啡依赖10天组，吗啡依赖10天对照组，吗啡依赖30天组，吗啡依赖30天对照组，脱毒组，脱毒对照组。
Methods:The firing of ventral pallidal neurons in the action of morphine and naloxone was recorded and analyzed in the morphine dependent rats with extracellular single-unit recording.
方法：通过单细胞细胞外记录吗啡依赖大鼠腹侧苍白球的电信号，观察吗啡对放电的影响。
Conclusion: Both spinal and supraspinal neuronal Phosphoinositide 3-kinase (PI3K) pathway played important role in morphine dependent and naloxone-precipitated withdrawal response in mice.
结论：脊髓和脊髓上中枢神经元pi - 3 K信号通路均参与吗啡依赖的形成及戒断反应的表达。
In addition, the withdrawal symptoms precipitated by naloxone in morphine dependent rats were blocked by methoctramine(ip) or pirenzepine (it) at single dose injection in a dose dependent manner.
美索四氨或哌拉唑嗪以剂量依赖方式抑制吗啡依赖大鼠纳洛酮激发的戒断症状。
Background: Although morphine has been shown to induce bowel dysfunction in a dose-dependent fashion, in most relevant studies it was investigated in single bolus injection.
背景：吗啡会引起肠蠕动失调，而且是以剂量效应的方式来表现，只是之前这类的研究是以单次剂量的给予来探讨。
Results: The injection could attenuate abstinent syndrome of rats, restore rat weight and reduce NA, DA and 5 - ht content in brain tissue of morphine -dependent rats.
结果经参附注射液治疗的大鼠戒断症状明显减轻，体重明显恢复，脑组织中NA、DA、5-HT等单胺类神经递质水平显著降低。
Results: The injection could attenuate abstinent syndrome of rats, restore rat weight and reduce NA, DA and 5 - ht content in brain tissue of morphine -dependent rats.
结果经参附注射液治疗的大鼠戒断症状明显减轻，体重明显恢复，脑组织中NA、DA、5-HT等单胺类神经递质水平显著降低。
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