Shopping becomes a major problem, and for anything slightly out of the ordinary you have to go on an expedition to the nearest large town.
购物成了大问题，要想买到任何一种稍不寻常的东西，你就得赶远路到最近的市镇。
Using mismatched ellipsoid models in your data is not generally a major problem.
在数据中使用不匹配的椭圆体模型一般是主要问题。
Lack of food is going to be a major problem in Somalia for the rest of this year.
今年其后的几个月里食品欠缺将会是索马里最严重的问题。
Although illegal logging has declined, it remains a major problem, the report says.
报道说，尽管非法采伐已经在减少，但依旧存在一个严重的问题。
One major problem with conventional "horizontal" farms is loss of water to runoff.
传统“水平”农场的水流失是一个重要问题。
Its population is rapidly aging, which looms as a major problem over the next 30 years.
人口也正在迅速老龄化，这个问题在以后30年内将越来越突出。
A major problem with supplements is that they deliver vitamins out of context, she says.
她还说，需要“补充维他命”这种现象的主要问题是：人们已经舍本逐末了。在水果和蔬菜当中我们就可以发现维他命。
Finally, one of the major problem areas of this mapping is XML element attributes mapping.
最后，该映射的主要问题之一就是XML元素属性映射。
We experienced one major problem with multi-cell GUI components (see Figures 2 through 6).
我们遇到了一个针对多单元GUI组件的主要问题(参见图2到6)。
It might not be a major problem for desktop applications, but it can bring a server to its knees.
对于桌面应用程序来说，这可能不是主要问题，但是它可能导致服务器瘫痪。
While these methods may help tame the tangle of options, they suffer from one major problem: bias.
这些方法有助于解决选择的困惑，但却要面临另一个重大的问题：偏见。
There's one major problem: Kamusi is broke, and development of the project has slowed as a result.
现在有个大的问题：Kamusi破产了，导致项目进展缓慢。
Yet if women were spending time together and not talking, it would be indicative of a major problem.
要是女人们聚在一起却不说话，那就意味着出现了大麻烦。
At this point you might be thinking that there is a major problem with both long polling and streaming.
至此，您可能会想，长轮询和流都有一个很大的问题。
How manages the good enterprise staff's information, becomes in the business management a major problem.
如何管理好企业员工的信息，成为企业管理中一个大的问题。
She said that God was not through with me yet; there was no way that this was going to be a major problem.
她说上帝还不想抛弃我，不会有什么大问题。
The report on the simulation, obtained by TIME last week, warns that transportation would be a major problem.
就在上周，时代周刊得到了这份模拟演习的报告，报告中警告说交通将是一个主要的问题。
"In the face of increasing complexity, and increasing data, we're faced with a major problem," Dr.McGill said.
“不断增加的复杂性和越来越多的数据让我们面临着大难题，”麦克吉尔博士说。
Bafana Khumalo, its international programmes manager, says: "We certainly have a major problem in South Africa.
该网络的国际项目经理Bafana Khumalo说：“当然，我们在南非面临着一个大难题。
One major problem is that because the applications are deployed separately, they all use different class loaders.
一个主要的问题是，由于应用程序都是分别部署的，因此它们全都使用不同的类装入程序。
Although the pianos are out on the streets for several days, Luke Jerram says vandalism hasn't been a major problem.
卢克·杰拉姆表示虽然钢琴放在街上已有几日了，破坏行为还不成为问题。
This has been a major problem when using Web services as part of a distributed transactional enterprise application.
这已经成为在使用Web服务作为分布式事务企业应用程序一部分时，主要的问题。
So it's a bit like antibiotics: Only if you have excessive use of antibiotics, does resistance become a major problem.
有点像抗生素：只有你大量服用抗生素的时候，抗药性才变成一个大问题。
If not architected correctly from the very beginning, enterprise data access can become a major problem down the road.
如果每次一开始都不能正确的架构，企业数据存取将成为一个主要拦路虎。
But that raises a major problem of demarcation and again this is the problem that has echoed down the centuries since.
但那又引出了关于界限划分的问题，这个问题在历史长河中再次回荡百年。
In contrast, more than half said it was a major problem that 42 percent of those starting at the bottom will remain there.
相反，多于一半的人说主要问题是42%的生于底层的人将会一直呆在那一个层次中。
Also, by being tightly controlled and vertical, Apple has solved a major problem in the computer industry: customer support.
同样，即时被严格控制和垂直的，苹果还解决了电脑行业的一个大难题：用户支持。
Back when Visual SourceSafe was the DE facto version control for Windows developers, remote access was a major problem.
回到VisualSourceSafe仍是Windows开发者的实际版本控制的时期，远程访问是其主要的问题。
Back when Visual SourceSafe was the DE facto version control for Windows developers, remote access was a major problem.
回到VisualSourceSafe仍是Windows开发者的实际版本控制的时期，远程访问是其主要的问题。
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