The sufferer may have to make major changes in his or her life to arrest the disease.
患者可能得对自身生活作大的调整以抑制病情。
It will not have escaped your notice that there have been some major changes in the company.
你肯定会注意到公司已经发生了一些重大的变化。
We do not own the building. Thus, it would be impossible for us to make any major changes to it.
我们不是这栋楼房的房主，因此不能对它进行大改动。
Britain, in common with many other industrialized countries, has experienced major changes over the last 100 years.
与许多其他工业化国家一样，英国在过去100年里经历了重大的变化。
Britain has experienced major changes in the last 100 years.
在过去的100年里，英国经历了很大的变化。
Two major changes—satellite and Internet radio—will force radio advertisers to adapt their methods.
两个主要的变化——卫星和网络广播——将迫使广播广告商调整他们的方法。
These developments have caused major changes like additional erosion of the Earth's surface and deforestation.
这些发展导致了重大变化，如地球表面的进一步侵蚀和森林砍伐。
We know that over the past millennia the climate has undergone major changes without any significant human intervention.
我们知道，在过去的几千年里，气候在没有任何大型的人为干预之下发生了剧大变化。
The major changes that relate to the user interface are.
与用户界面相关的主要修改如下。
Major changes in laws and compliance regulations across jurisdictions.
法律和法规出现了重大变化。
John Rose's blog contains a summary of the major changes. Amongst them.
JohnRose的博客对主要的变化进行了总结，如下所示。
Backward compatibility is maintained between major changes in libraries.
程序库的重要变化之间保持了向后兼容性。
If you slip up, don't give up! Major changes sometimes have false starts.
如果你遇到一些挫折，请不要就此放弃有时候一些重大的改变始于错误的开始。
This decoupling of the Asian-western consensus could lead to major changes.
东西方之间共识的脱钩，可能会导致重大变化。
The context for transport services and infrastructure is marked by major changes.
运输服务和基础设施的背景发生了显著的变化。
It's a prize that could help us understand what drives major changes in Earth's climate.
其成果将帮助我们理解究竟是什么驱动了主要的全球气候变化。
The Virtual Memory Manager (VMM) undergoes major changes for a partitioned environment.
对于分区的环境，虚拟内存管理器(VMM)经历了较大的更改。
Have there been major changes in the business that require a new design and new information?
还是因为发生了业务发生了重大改变需要新的设计与信息？
One of the other major changes was in the repackaging and restructuring of the entire source code.
另一项重大变化是重新打包和组织了全部源代码。
Unfortunately, most of these are major changes that require you to create a whole new web service.
不尽人意的是，在这些类型的大部分改变中，主要的变化是要求您创建全新的Web服务。
Stern has served as commissioner for close to 30 years and has overseen major changes at the league.
斯特恩担任NBA总裁的时间已接近30年，指导联盟做出了几项重大变革。
Major changes in core libraries can also present a problem when trying to achieve binary compatibility.
当尝试获得二进制兼容性时，核心程序库的重要变化也会引发问题。
Yahoo has to endure some major changes no matter what, but nobody seems to know what they should be.
无论如何，雅虎都将经历一场剧变，但没人知道它将走向何方。
But no humans had yet set foot in the Americas, and it needed major changes in climate before they could.
然后仍旧没有任何人类踏足到美洲的土地上，事实上只有到气候产生了重要变化之后，这种时机才能成熟。
XNI was declared stable almost two years ago and it is not expected to undergo major changes in the future.
XNI公布差不多有两年了，一直很稳定，估计将来也不会有大的变化。
It repeats the processes in response to major changes in system context, goals, constraints, and risks.
该框架响应系统上下文、目标、约束和风险方面的重大更改而重复执行流程。
For major changes to a business process, the BPEL model should be re-generated from WBM and imported into WID.
对于业务流程的重要更改，应该从WBM重新生成BPEL模型并导入到WID中。
Here also the major initiatives that are the basis of any change and that will bring major changes to your life.
主要行动同时也是任何变化的基础，会给你的生活带来最主要的变化。
A sharp drop in smoking has had a huge impact on heart health. And major changes in diet have also played a role.
吸烟情况的大量减少大幅度地促进了心脏健康，而对大多数饮食习惯的改变也起到了积极作用。
Google local time in the United States on Thursday announced that its search engine algorithms to make major changes.
谷歌在美国当地时间星期四宣布对其搜索引擎的算法作出重大修改。
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