There is already a targeted treatment for this disease. Gleevec, probably the most remarkable anti-cancer drug of the past decade, disables the protein encoded by another fused gene, BCR-ABL.
现在对这种病已有针对性疗法，Gleevec大体是过去十年中效果最显著的药物，它能使另一融合基因BCR-ABL的编码蛋白失去活性。
But the kinds of cells they independently studied could not be used to create gene-targeted animals.
但是他们各自所研究的细胞类型不能用来培育基因靶向动物。
If it works in people, it would provide a highly targeted mechanism for delivering cancer-fighting gene therapy.
如果这种方法在人体有作用，就将提供一种高度靶向抗癌基因治疗的新方法。
Targeted gene expression to the epidermis has been achieved, but was neither a prerequisite for correction nor did it improve longevity of expression.
皮肤靶向基因的表达已完成测序，但这并不是我们就能对它进行修饰的先决条件。
A major goal of tumor-targeting gene therapy is to transfer genes efficiently to tumor cells by targeted vectors.
肿瘤靶向基因治疗的主要目的是用靶向性的载体将治疗基因靶向传递到肿瘤细胞。
Linkage disequilibrium analysis is a effective way to identify the function of the of the gene (or targeted high-resolution QTL).
连锁不平衡分析是对基因(或已定位的高分辨率QTL)的功能进行鉴定的有效方法。
Vector tropism is a research hot spot in cancer gene therapy, and targeted viral vectors play a key role in the enhancement of safety and efficiency in cancer gene therapy.
病毒载体的靶向性问题是肿瘤基因治疗中的重要研究热点，靶向病毒载体是提高肿瘤基因治疗安全性和有效性的重要途径。
The progress of drug loaded intravenous lipid emulsions in enhancing drug solubility and stability, reducing side effects, sustained release, targeted delivery and gene therapy is introduced.
介绍了静脉注射用脂肪乳剂在提高药物溶解度和稳定性、减轻药物不良反应、缓释、靶向给药和基因治疗等方面的研究进展。
Objective To construct and study the targeted gene therapy system for growth hormone- secreting pituitary tumors.
目的构建并评价垂体生长激素腺瘤靶向性基因治疗系统。
Targeted disruption of the murine Nkx2.5 gene results in abnormal heart morphogenesis, severe growth retardation, and embryonic lethality around E9.5 (1, 2).
靶向缺失小鼠nkx2.5基因会导致心脏形态异常，严重的发育迟缓以及E9.5胚胎致死(1,2)。
Targeted gene therapy in the course of chemotherapy has achieved remarkable results, now in recent years, targeted gene therapy of acute lymphoblastic leukemia research are summarized below.
靶向基因治疗在化疗过程中取得明显效果，现将近年来靶向基因治疗急性淋巴细胞白血病的研究进展综述如下。
Objective to construct and evaluate the receptor targeted gene therapy system for pituitary adenoma.
目的构建并评价受体靶向性基因导入系统对垂体腺瘤的靶向性治疗作用。
This can be achieved by tumor targeted gene transfer or tumor specific gene expression, as well as secretion of tumor targeted therapeutic molecules by autologous normal cells.
这种靶向性的策略包括目的基因对肿瘤细胞的靶向转移，目的基因在肿瘤细胞中的特异表达，以及基因修饰细胞分泌的肿瘤靶向治疗分子。
The study team targeted the gene by giving trial participants a mimic of its natural target, ribavirin.
该研究团队为参加扎提供了一种模拟其天然靶点——利巴韦林，借此靶向研究其基因。
All 3 ESS were found to harbor ZC3H7B-BCOR gene fusions by targeted sequencing and fluorescence in situ hybridization.
通过靶向测序和荧光原位杂交技术发现，3例均存在ZC 3h7b -BCOR基因融合。
Therefore, seeking for indicators of early diagnosis of malignant tumors and to find targeted therapy of gene has gradually become a research direction.
因此，寻找恶性肿瘤的早期诊断指标以及寻找基因的靶向治疗方法逐渐成为一个研究的热点。
The researchers found that in drug-resistant patients, found a gene called MET, which was targeted to activate and become resistant to treatment.
研究人员发现，在耐药的病人中，发现了一个叫MET的基因，后者被靶向治疗药物激活并产生耐药。
The researchers found that if the drugs inhibit MET gene amplification will enable the efficient targeted therapy of lung cancer from 71% to 93%.
研究人员发现，如果用药抑制MET基因的扩增，可以使肺癌靶向治疗的有效率从71%提高到93%。
Molecular marker-assisted selection (MAS) provides a very efficient tool for backcross breeding because it can offer rapid and precise selection of the targeted gene.
分子标记辅助选择技术以其对目标基因快速而精确的选择为回交育种提供了非常有效的工具。
The strategy targeted to the tumor suppressor gene that regulates the cell cycle directly, obtained satisfactory results, and provided a reliable theory for lung cancer gene therapy.
本项基因治疗策略以直接调控细胞周期的抑癌基因为靶向治疗基因，为肺癌基因治疗提供了可靠的理论依据。
Objective To investigate the use of albumin-coated microbubbles targeted delivery report gene by therapeutic ultrasound-mediated microbubble destruction.
目的探讨白蛋白包裹微泡在治疗超声照射下对基因传输的作用。
The ultimate goal of gene therapy is correction of the genetic disorders by introducing the genetic materials into targeted cells, and gene expression should be permanent and at an appropriate level.
基因治疗的目的是将遗传物质导入细胞并使之得到适宜水平的表达，以纠正机体的遗传缺陷，恢复细胞的正常功能或杀死癌细胞及致病微生物。
AIM: To explore targeted gene therapy of tumor by using the combination of TRAIL gene with the telomerase promoter.
目的：研究TRAIL基因结合端粒酶启动子特异性靶向治疗的作用。
The targeted gene in the process is one that codes for the Oct4 transcription factor, which allows embryonic stem cells to remain pluripotent.
在这一过程中的目的基因是一个可以编码OCT4转录因子，让胚胎干细胞维持多能性。
Objective To investigate the effect of dual-target antisense RNA of hepatitis B virus (HBV) targeted to X and P region on replication and expression of HBV gene in HBV transgenic mice.
目的探讨针对乙型肝炎病毒（HBV）x、p双靶区反义RNA对乙型肝炎病毒转基因小鼠HBV复制和表达的影响。
The GUCY2D gene therapy effort is one of six new Foundation-funded gene therapy projects that are targeted to move into clinical trials within three years.
GUCY2D基因治疗的努力是六个新的基金会资助的基因治疗，有针对性地在三年内进入临床试验项目之一。
CXCR4-targeted therapeutic approaches will become a new hot point in the research of tumor gene therapy.
针对CXCR4靶向治疗将成为肿瘤基因治疗研究的新热点。
All these show that fibroblast cells harvested and cultured in this method could be safe and stable targeted cells used for the study of gene therapy of autologous skin fibroblast.
从而证明该方法所获取的大量皮肤成纤维细胞可作为一种安全、可靠的靶细胞用于自体皮肤成纤维细胞基因治疗研究。
Objective to modulate the molecular conformation of the hepatocyte targeting drug to increase exogenous gene expression efficiency in the targeted cell.
目的：用调整肝细胞靶向基因药物分子构形的方法，以期提高外源转入基因在目标细胞的表达效率。
Objective to modulate the molecular conformation of the hepatocyte targeting drug to increase exogenous gene expression efficiency in the targeted cell.
目的：用调整肝细胞靶向基因药物分子构形的方法，以期提高外源转入基因在目标细胞的表达效率。
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