Cystic Fibrosis (CF), caused by mutations in the CFTR gene, is one of the most common inherited disorders of white populations.
囊性纤维化(CF)是白人中最常见的遗传性疾病之一，由CFTR基因突变造成。
Mutations of CFTR may lead to the lethal genetic disease Cystic fibrosis (CF), so many attentions have been paid to the CFTR study.
CFTR由于其突变能导致致命性遗传疾病CF而备受关注，人们对其结构、功能进行大量研究取得了很大成果。
BACKGROUND Increasing the activity of defective cystic fibrosis transmembrane conductance regulator (CFTR) protein is a potential treatment for cystic fibrosis.
背景提高有缺陷的囊性纤维化跨膜电导调节(CFTR)蛋白的活性是囊性纤维化的一种潜在治疗。
Although it is known that mutations in the CFTR gene cause the disease, variations in other genes between individuals with CF modify the severity of the disease.
虽然，囊性纤维跨膜通道调节因子基因（CFTR）突变是这种疾病的病因，但在患有CF的病人之间的不同基因的变异会改变这种疾病的严重度。
Researchers Erich Gulbins, MD, PhD, of Germany's University of Duisburg-Essen and colleagues now find that CFTR dysfunction upsets a delicate chemical balance in the lungs.
现在，德国Duisburg - Essen大学研究人员ErichGulbins博士和他的同仁们发现CFTR的异常扰乱了肺部精细的化学物质平衡。
Newborn pigs lacking CFTR showed defective chloride transport and developed meconium ileus, exocrine pancreatic destruction, and focal biliary cirrhosis, which are all hallmark of CF disease.
新生的缺乏CFTR基因的猪表现出氯化物转移缺陷，胎粪性肠梗阻，胰腺外分泌缺陷和局限性胆道硬化，而这些症状正是人类CF疾病的主要症状。
Newborn pigs lacking CFTR showed defective chloride transport and developed meconium ileus, exocrine pancreatic destruction, and focal biliary cirrhosis, which are all hallmark of CF disease.
新生的缺乏CFTR基因的猪表现出氯化物转移缺陷，胎粪性肠梗阻，胰腺外分泌缺陷和局限性胆道硬化，而这些症状正是人类CF疾病的主要症状。
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