Children and adolescents with bipolar disorder generally are treated with lithium, but valproate and carbamazepine also are used.
儿童和青少年患者常使用锂盐治疗，但也使用丙戌酸钠和卡马西平。
ABSTRACT Objective: To study the influence of sodium valproate on plasma fibrinogen.
目的：研究丙戊酸钠对血浆纤维蛋白原的影响。
There were no significant differences between the levetiracetam and valproate groups.
左乙拉西坦组与丙戊酸钠组差异无统计学意义。
As a first - line agent for treating epilepsy, valproate sodium is widely used in clinic.
丙戊酸钠作为常用一线抗癫痫药，目前在临床的应用较为广泛。
The effects of the blood concentration weren't great on TPM to carbamazepine and valproate.
TPM对卡马西平及丙戊酸钠血药浓度影响不大。
OBJECTIVE to explore the pathogenesis of thrombocytopenic purpura caused by sodium valproate treatment.
目的探讨丙戊酸钠致血小板减少性紫癜可能发生机制。
Objective: to compared the pharmacokinetics of sodium valproate suppository with sodium valproate tablets.
目的：比较丙戊酸钠栓剂与片剂的药代动力学特征。
AbstractObjectiveTo investigate the effects of valproate treatment on plasma insulin and leptin levels of epileptic children.
目的探讨丙戊酸治疗对癫疒间患儿血浆胰岛素和瘦素水平的影响。
Objective To investigate the clinical efficacy and side effects of sodium valproate in the treatment of alcohol withdrawal reaction.
目的探讨丙戊酸钠对酒精戒断反应的临床疗效及副反应。
ConclusionBorneol can enhance the permeability of blood-brain barrier to sodium valproate, but has small influence on blood concentration.
结论冰片可提高血脑屏障对丙戊酸钠的通透性，但对血药浓度影响较小。
Neither sodium valproate nor Verapamil showed any effect on action potential amplitude, overshoot, resting potential and phase o upstroke velocity.
丙戊酸钠和异搏定对动作电位幅度、超射值、静息电位、O期最大除极速度均无明显影响。
METHODS: the serum concentrations of valproate in 276 patients were determined by fluorescence polarization immunoassay and the results were analyzed.
方法：采用荧光偏振免疫法测定276例癫痫患者的丙戊酸血药浓度并分析结果。
Conclusion: Lower dose sodium valproate is effective in the treatment of TD caused by antipsychotics. Close attention should be paid to the platelet count.
结论：丙戊酸钠治疗抗精神病药所致TD有效，但以低剂量为宜，应注意监测血象。
AIM: To observe the effects of sodium valproate in the repair of rat sciatic nerve injury through the drug experiment of the model of sciatic nerve injury.
目的：通过对坐骨神经损伤模型的药物实验研究，观察丙戊酸钠对大鼠周围神经损伤的修复作用。
Objective: to evaluate the efficacy and side effects of sodium valproate and carbamazepine in the treatment of manic episodes refractory to lithium carbonate.
目的：评价丙戊酸钠与卡马西平对锂盐治疗无效的躁狂发作的疗效和副反应。
CONCLUSION: This HPLC-fluorescence method is quick, sensitive and economical, which can be used to monitor the concentration of sodium valproate in human serum.
结论：本检测方法快速、灵敏、经济，可用于监测人血清中丙戊酸钠的浓度。
CONCLUSION: in therapeutic drug monitoring of valproate, it should be concerned about the impact factors of valproate concentration to ensure the safety and efficacy in patients.
结论：在丙戊酸治疗药物监测中，要关注影响丙戊酸血药浓度的因素，确保患者用药安全有效。
All rats were randomly divided into six groups: KXZZ high-does group, KXZZ middle-does group, KXZZ low-does group, valproate magnesium group, model group and normal control group.
实验大鼠随机分为中药高剂量组、中药中剂量组、中药低剂量组、丙戊酸镁组、模型组、正常对照组。 观察各组大鼠的惊厥潜伏期；
Methods: Seizures in the group of epileptic rats induced by penicillin, the group of the LTG, and the group of the sodium valproate were measured, and the EEG was recorded for the groups.
方法：观察青霉素致痫组、拉莫三嗪组、丙戊酸钠组大鼠痫性发作，并记录其脑电图。
The risk of developing a rash is higher if taking lamotrigine while also taking valproate or divalproex sodium or if taking a higher starting dose or increasing the dose faster than prescribed.
如果使用拉莫三嗪的同时使用了丙戊酸钠或双丙戊酸钠，或者采用了更高的起始剂量，或是增加剂量速度过快都有可能增加发生皮疹的风险。
The birth defect rate was highest among women who took Topamax in combination with the epilepsy drug valproate, which has been linked to birth defects in numerous studies and epilepsy databases.
在妥泰联用抗癫痫药丙戊酸盐的女性中出生缺陷发生率最高，后者已被许多研究结果和癫痫数据库认定与出生缺陷相关。
Conclusion Sodium valproate and phenytion sodium have the certain clinical efficacy in treatment of generalized tonic-clonic seizure. But phenytion sodium has the more and worse untoward reaction.
结论丙戊酸钠、苯妥英钠治疗癫痫全面性强直阵挛发作疗效肯定，但苯妥英钠不良反应多。
Objective: Antiepileptic drugs (AEDS) may affect serum thyroid hormone concentration. this study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), or valproate (VPA) for epilepsy.
目的抗癫痫药物可以引起甲状腺激素水平改变，本研究旨在探讨抗癫痫药卡马西平(CBZ)、丙戊酸钠(VPA)对男性癫痫病人甲状腺激素水平的影响。
Results: After 1 week and 4 weeks treatment, the total scores of PANSS, scores of positive symptoms and psychopathology were significantly decreased in sodium valproate group than in controlled group.
结果：合用组治疗1周后及治疗结束时PANSS量表总分、阳性症状、精神病理症状的评分比单用组明显为低。
Valproate was FDA-approved in 1995 for treatment of mania.
1995年，丙戌酸钠被FDA核准用于治疗躁狂。
Valproate acid had no influence on fasting serum insulin level of epileptic patients, but can increase their fasting serum leptin level, especially obese epileptic patients.
丙戊酸对癫痫病人空腹胰岛素水平无明显影响；可显著增加癫痫病人的空腹瘦素水平，尤其是肥胖病人。
Valproate acid had no influence on fasting serum insulin level of epileptic patients, but can increase their fasting serum leptin level, especially obese epileptic patients.
丙戊酸对癫痫病人空腹胰岛素水平无明显影响；可显著增加癫痫病人的空腹瘦素水平，尤其是肥胖病人。
应用推荐