Objective To investigate the features of somatic mutations and polymorphisms of mitochondrial D loop regions in breast cancer.
目的探讨乳腺癌的线粒体基因D环区的体细胞性突变和多态性变异特征。
Tumor biopsies were evaluated for the presence of somatic mutations in exons 18-21 of EGFR and exon 2 of RAS by bi-directional sequencing.
对肿瘤组织进行或组织检查以检测EGFR的18—21外显子的突变并应用双向测定法检测RAS的2外显子的突变。
To arrive at these conclusions, researchers analyzed about 500,000 cancer mutation records from the Catalog of Somatic Mutations in cancer database and then divided the data into 45 tissue types.
为了得到这些结论，研究者在癌症数据库细胞突变分类中分析了大约50万条癌突变记录，并把这些数据分为45种组织类型。
Somatic mutation, a main biological phenomenon of citrus and other fruits, is often used for breeding as a major variation source. Spontaneous mutations often occur in citrus.
体细胞突变是柑橘等果树比较常见的生物学现象，也是品种选育，即芽变选种的主要变异来源。
Moreover, somatic point mutations were associated with specific clinical features and prognosis.
此外，体细胞点突变与特定临床特征及预后相关。
Recurrent mutations were found in 10 genes and the somatic nature of these mutations was analyzed by comparison with generic DNA from buccal swabs.
在10个基因中发现频发突变，通过与口腔拭子中的基因组d NA比较分析这些突变的体细胞特征。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 （CREBBP 与 CTCF）的基因。
Of the 52 somatic nonsynonymous mutations found in 32 genes they found two genes involved in histone modification (CREBBP and CTCF).
他们在32个基因的52个体细胞非同义突变中找到了2个参与组蛋白修饰 （CREBBP 与 CTCF）的基因。
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