Could RNA interfere with prion disease?
RNA能否干预普粒子疾病？
Objective Preparing specific antibody to prion protein.
目的制备针对朊蛋白的特异性抗体。
What route does the prion follow from the mouth to the brain?
朊蛋白通过什么途径从嘴巴进入大脑？
Can the "flipped" BSE priori induce the normal human prion to flip?
这种“变形的”BSE普里安能诱发正常人普里安发生改变吗？
Prion protein is a normal constituent of brain tissue in all mammals.
朊蛋白是一种脑组织中所有的哺乳动物的正常组成部分。
The essence of prion (proteinaceous infectious particle) is a protein.
朊粒的本质是蛋白质。
Prion is the pathogen that caused infectious spongiform encephalopathy.
朊蛋白是传染性海绵状脑病的致病蛋白。
Prion diseases affect the brains of a number of mammals, including humans.
普利子疾病能影响许多哺乳动物的大脑，包括人类。
By exhaustive enumeration, we get the prion-like behavior of protein folding.
通过穷举计算，我们观察到了这种折叠行为。
These are quite effective in reducing the prion levels of cultured nerve cells.
它能有效降低体外培养的神经细胞内的朊病毒水平。
But it's not yet known whether the variant protects against other prion diseases.
但是目前还不清楚这一变异是否对其他由朊病毒引起的疾病有效。
Researchers have struggled to determine what prion proteins normally do in the brain.
学者致力于研究朊蛋白在脑组织中起什么作用。
What is even more peculiar: exactly the same prion proteins occur in healthy animals.
更奇特的是：这种蛋白质在健康动物中也存在。
The malformed prion proteins can be deposited in the brain, thereby destroying brain tissue.
致病性的朊病毒蛋白质在脑中沉积并损伤脑组织。
It suggests that human prion protein might play a role in controlling cell programmed death.
这提示朊蛋白可能参与细胞程序化死亡的调控过程。
We should transform the traditional medical thinking model to research the mystery of prion.
必须转变固有的医学思维模式来看待朊病毒之谜，并从哲学角度探讨了朊病毒病的出现。
There's hope that by disentangling PrP's normal job, prion diseases will become easier to understand.
PrP及朊病毒疾病的的常规研究将有可能变得更加容易理解。
So drugs that prevent this amyloid - prion coupling could be a potent weapon against Alzheimer's.
所以能防止淀粉样蛋白和朊病毒蛋白结合的药物可能会成为治疗老年痴呆症的强有力武器。
The molecular changes did not, though, seem to change the aminothiazoles' prion-killing attributes.
氨噻唑分子的改变似乎并没有改变其杀灭朊病毒的特性。
Together with his colleagues, he studied four different strains of mice lacking the gene for the prion PrPC.
他和他的同事们研究了四种缺少这种蛋白基因的老鼠。
However, prion diseases are considered to be representative of other protein precipitation-associated diseases.
然而，阮病毒疾病被认为是其他蛋白相关疾病的典型。
CJD is a progressive fatal neurodegenerative disorder caused by prion proteins accumulating within the neurons.
CJD是一种进行性致命性神经变性疾病，是由于朊病毒在神经元内堆积所致。
In fact, at first glance, lack of prions seemed like a good thing because it made mice immune to prion infection.
事实上，在初期，缺少这种蛋白看起来和正常情况一样，因为它使老鼠免疫这种蛋白的缺失。
However, the prion protein in scrapie-infected brain tissue differs from normal prion protein in some of its properties.
然而，在感染羊瘙痒病的大脑组织的普利昂蛋白在某些性质上不同于一般的普利昂蛋白。
Objective To investigate the effects of prion protein 106-126 peptide on inducing apoptosis in differentiated PC12 cells.
目的：研究朊蛋白106-126肽段在细胞水平上的毒性作用。
Prion diseases are always fatal, often, however, not until months after the outbreak of the disease. As yet there is no cure.
朊病毒病是致命的，常常在发病后数月死亡，但是目前还没有有效的治疗方法。
The prion-protein genes are single-copied and high conservative, but there might be related munity gene existing between animals.
朊蛋白基因是单拷贝基因，高度保守，但在物种间可能存在易感性相关基因。
Conclusion Prion protein 106-126 peptide can induce apoptosis in differentiated PC12 cells and present cellular toxicity definitely.
结论：朊蛋白106- 126肽段能够诱导分化后的PC 12细胞凋亡，具有明确的毒性作用。
In 2003, Mead and his colleagues discovered a much more common variant of the prion gene that provides protection against prion diseases.
2003年，米德和他的同事发现了朊病毒基因更普遍的变体，可以抗御与朊病毒有关的疾病。
The prion entered the human food chain without evident symptoms being observed - the pathogen was able to jump the species gap to humans.
在不引起可见的明显的症状的情况下，朊蛋白进入了人类的食物链，它可以跨过物种差异感染人类。
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