So you made somehow an anti-sense polynucleotide to the insulin gene or some fraction of the insulin gene.

这样你就合成了,胰岛素基因的反义多聚核苷酸链,或者说胰岛素基因的片段

耶鲁公开课 - 生物医学工程探索课程节选

The one that does is called the sense strand and the other one is called the anti-sense strand, anti meaning it's the compliment and it will hybridize to the sense.

能够进行编码的一条链叫做正义链,另一条则叫做反义链,反义的意思是它与正义链互补,并能够与之杂交

耶鲁公开课 - 生物医学工程探索课程节选

If somehow you could take your anti-sense molecules that you've made and you could get them into cells, then by this process of hybridization they would naturally form a pair like this.

如果你能得到合成的反义链,并能使它进入细胞,那么通过杂交,它们就能自然形成这样的一对

耶鲁公开课 - 生物医学工程探索课程节选

Well, that anti-sense strand is shown here as the red and the cell is naturally making the blue or sense strand of messenger RNA for a particular protein.

好的,反义链在这里以红色表示,细胞自身会造出合成某种,特定的蛋白质的蓝色RNA正义链

耶鲁公开课 - 生物医学工程探索课程节选

Now the nice thing about this is that the degradation mechanisms seem to persist for some period of time, beyond the time at which you deliver the double stranded RNA; whereas, obviously, this mechanism here is only going to exist for as long as the anti-sense sequence is present.

而好消息是降解过程会持续一段时间,比你转入双链RNA的时间要长,但是,这种机制只会在,有反义链的时候发挥作用

耶鲁公开课 - 生物医学工程探索课程节选