-
So, there's no absolutes about this, this is a general response where all the features can be different with different pathogens.
这其中并没有明确的规律,免疫应答是普遍存在的,但针对不同的病原体的应答规律各不相同
-
Memory cells are long lasting cells that remember this exposure and can respond very quickly on second exposure.
记忆细胞可以长时间记忆与抗原的接触,并在再次免疫中迅速做出应答
-
But because of the similarity of the viruses, the immune response that people developed would also protect them against natural infections with variola.
因为这两种病毒很相像,人体的免疫应答也能保护自己,免受天花的感染
-
So, you couldn't introduce the live virus in because that would cause the disease not just immunity.
所以 不可以直接接种活体病毒,因为这会使人致病而不仅是引起免疫应答
-
Now, just--what this diagram also shows you is that that response is specific to that particular antigen.
看,就像这幅图表展示的一样,免疫应答是针对特定的抗原
-
And those words mean different things: immunogenic means that it stimulates your immune system for a response; pathogenic means that it causes a disease.
这两个词有不同的意义,免疫效应是指,刺激免疫系统产生免疫应答,致病性意指它能使你患病
-
Some, like the smallpox vaccine on one exposure generates a very high response that lasts for many years so you don't need a boost.
有一些疫苗,比如接触一次天花疫苗后,人体就能产生高水平的免疫应答,并持续很多年,所以无需再次接种
-
That would be a subunit vaccine because I'm purifying a subunit of the virus that could be injected and hopefully induce an immune response.
那将会产生疫苗,因为我提取的是病毒的亚基,可以被注射并且有可能引发免疫应答
-
It's not just that your whole immune system gets revved up and it's going to respond more rapidly to any antigen it's exposed to.
并不是整个免疫系统都得以加强,免疫应答会对,以前接触过的抗原做出的应答更加迅速
-
Now, why do you need a cell mediated immune response if you have an antibody response?
为什么你还要有细胞免疫反应呢,你已经有抗体应答了啊
-
Then, your muscle cells would start producing Hepatitis B surface antigen and your immune system recognizing that's a foreign protein would start responding to it.
于是,肌肉细胞将会,开始制造乙肝表面抗原,然后免疫系统就会识别出,那是外来蛋白质并且产生免疫应答
-
The response to the second exposure in antigen is different in a couple of ways.
第二次接触相同抗原,免疫系统的应答,在以下几个方面是不同的
-
Probably it wouldn't, you would probably get a little bit sick anyway, but recover.
或许免疫应答还做不到这一点,你可能仍会小病一场,但很快就康复
-
Now, t-cells are also involved in humoral immunity but they're not the end result.
细胞也参与体液免疫,但它并不是体液免疫的最终应答结果
-
That shouldn't be too surprising given what we talked about last week, that your immune system, the adaptive immune system in particular, responds to individual antigens differently.
你们不必惊讶,上周我们讲过免疫系统,特别是适应性免疫系统,对不同抗原的应答是具有特异性的
-
Because this is not a virus at all, but it's a virus subunit, your body doesn't respond to it as strongly, your immune system doesn't respond to it as strongly.
因为这根本不是病毒,而是一个病毒亚基,机体对其反应不是那么强烈,免疫系统不会产生强烈的应答
-
Others generate a weaker response that does require boosting.
还有一些疫苗产生的免疫应答较弱,这种疫苗就需要再次接种
-
The answer is "Yes you would", the question is "Would that response, even though it's much faster, be fast enough to protect you from the initial exposure to tetanus that you got?"
是的,你的身体会马上做出应答,问题是 即便免疫应答十分迅速,但是否足够迅速,以保护你不被破伤风杆菌感染
-
But in any event, the vaccine is intended to stimulate the immune system to produce an effector response— either antibodies or specific cells— that can combat spread of the microorganism through your body.
但无论如何,疫苗是通过,刺激免疫系统来使身体产生应答,无论是抗体还是特定的细胞,都可以阻止微生物在体内扩散
-
Hopefully their immune systems will respond to it like the real virus but it won't be capable of replication because we've chemically cross linked it so it can't go through its life cycle.
人体的免疫系统,就会对该病毒产生免疫应答,但灭活的病毒不能复制,因为我们已经对它做了化学处理,使它无法进入生命周期
-
If we just thought about that second part of it, just the antibody generation, or the humoral what we called last time--last week, the humoral immune response, the immune response associated with humoral immune response of antibodies in the blood and in other fluids.
当我们仅考虑上述过程的第二步,也就是产生抗体的部分,或是我们上周学习的,体液免疫应答,这种免疫应答与,血液中以及其他体液中的抗体有关
-
So, these memory cells are a way that your immune system keeps track of antigens that it's been exposed to for even if maybe the plasma cells that were producing antibody in response to the initial exposure have died and disappeared.
所以,这些记忆细胞,是人体免疫系统记忆抗原的一种方法,即使由浆细胞产生的抗体,在初次免疫应答中全部被消灭,记忆细胞仍然能迅速分化为抗体分泌细胞
-
If the immune system recognizes only small pieces of the virus and mounts an immune response to that, how about if I just take these pieces of a virus like some structural subunit, some piece of protein and use that as a vaccine?
如果免疫系统识别出病毒的一小段,就可以诱发起免疫应答,那么如果我仅用一小部分病毒,比如一些结构性亚基 一些蛋白质的片段,来作为疫苗的话,会如何呢
-
The other part of the adaptive immune system is the cell mediated immune system and this is an immune where that doesn't involve antibodies but involves cells that are activated in response to a foreign antigen and that utilize cellular means to get rid of it.
获得性免疫系统还包括,细胞免疫,这一免疫反应不包含抗体,但包含可以被激活来应答,并清除外源抗原的免疫细胞
-
The other thing that I want to do today is try to tie this discussion on vaccines a little bit more closely with what we talked about last week, in terms of what happens inside your body when you receive a vaccine or when you're exposed to an antigen, and how the immune system actually responds to that.
还有就是,我希望可以,把今天关于疫苗的讨论,与我们上周讲过的内容,结合得更紧密一些,当接种疫苗,或者是接触抗原时,人体将会发生怎样的变化,以及免疫系统对疫苗产生何种应答
-
If we did the experiment where on this booster we included not only the initial antigen but some unrelated antigen, the response to the unrelated antigen called B here, looks like a primary response.
如果实验中我们使用的后续疫苗,不仅包括原抗原,还包括一些无关抗原,这里将对无关抗原的应答称为B,该应答就如同初次免疫一样
应用推荐