Sometimes subtle changes in the structure of a protein can convert it from an active state into an inactive state.

有时蛋白质结构上一些很小的变化,就能将其由激活态转变为非激活态

耶鲁公开课 - 生物医学工程探索课程节选

The other beauty about - beautiful thing about proteins is that if you make subtle conformational changes, often those changes are reversible.

蛋白质的另一个美妙之处就是,如果蛋白质发生一些小的构像改变,这些改变通常是可逆的

耶鲁公开课 - 生物医学工程探索课程节选

That - irreversible changes happen all the time too but here I'm talking about very subtle small changes where you're changing the structure of the protein but only a little bit such that it can go back.

这种不可逆的改变时时刻刻都在发生,但我在这里想讲的是,对蛋白质结构进行微小的改变,小到这种改变是可逆的

耶鲁公开课 - 生物医学工程探索课程节选