In this case here, you're generating host cells, cytotoxic T-cells, that can kill only very specific cells, cells that are expressing this foreign antigen.

而在这个例子中,人产生宿主细胞,即细胞毒性T细胞,它只会消灭特定的细胞,也就是携带特定异己抗原的细胞

耶鲁公开课 - 生物医学工程探索课程节选

We talked about host cells that are perhaps infected with a virus, displaying pieces of that virus, antigenic pieces of that virus in the context of a surface receptor called MHC-1, presenting that.

我们说到过,可能受到病毒感染的宿主细胞,表现出病毒的一部分特征,病毒的抗原部分,其表面受体称为主要组织相容性抗原-1,MHC-1负责呈递抗原

耶鲁公开课 - 生物医学工程探索课程节选

Took it out of the virus completely, cloned it into a plasmid, that plasmid was expressed in a foreign host, in this case it was expressed in yeast cells.

将基因从病毒中完全提取出来,并克隆制成质粒,该质粒在外来宿主中表达,此例中质粒在酵母细胞中表达

耶鲁公开课 - 生物医学工程探索课程节选

These released particles can now go on and infect neighboring cells, they can travel in the bloodstream to infect cells at a distance and the virus spreads throughout a multicellular host.

这些释放出的病毒颗粒,可以继续感染邻近的细胞,它们可以随着血流去感染远距离的细胞,于是病毒可以在多细胞宿主体内全面扩散

耶鲁公开课 - 生物医学工程探索课程节选

Then those antigens get expressed with MHC just like they did in all the other cells inside the host, but particular cells of the innate immune system have a different kind of MHC called MHC2.

这些抗原同MHC共表达,就如同抗原在其他宿主细胞中那样,但先天免疫系统有一类特殊的免疫细胞,具有一种称为MHC2的不同MHC

耶鲁公开课 - 生物医学工程探索课程节选

If you take an organ from one person and put it in another, if their MHC molecules don't match then the immune system recognizes the immune system of the host recognizes 'this is not the right MHC for me' and the immune tries to destroy those cells.

如果将器官从一个人移植到另一个人,免疫系统识别出MHC分子并不匹配,宿主的免疫系统就会说,这不是我的MHC,免疫系统就会试着摧毁移植器官的细胞

耶鲁公开课 - 生物医学工程探索课程节选