You make not small changes in their chemistry but big changes in their chemistry.

它们的化学性质,就会发生巨大的改变

耶鲁公开课 - 生物医学工程探索课程节选

But I had like, really, really big dreams, so I wanted to pursue in New York, which led me here.

但我有很伟大的梦想，我想在纽约实现这个梦想，这也是我来这里的原因。

耐克设计师 - SpeakingMax英语口语达人

Now Microsoft is sort of a funny place, we've got these big businesses but in the software business big businesses need to be constantly recreated.

现今的微软是非常有意思的地方，我们运行着庞大的生意，但是在软件交易上,大宗交易更像是消遣。

斯坦福公开课 - 微软CEO-Steve.Ballmer谈科技的未来课程节选

Now it's--I think it's still the dominant academic view, but there's a big debate and there are partisans on both sides.

现在，这种观点-我认为仍然是主流的学术观点，但是对此学术界也存在激烈的争论,并且双方都有自己的阵营。

耶鲁公开课 - 金融市场课程节选

You just can't just cast it away, and say it's no big deal. But because it is a deal.

总不能置之不理，想着反正天也不会塌下来，那你就错了。

斯坦福公开课 - 经济学课程节选

They're producing electrical signals in the brain they're not recording from the brain, but it's not that big of a difference.

它们只能向大脑发出信号,而不能记录反馈大脑的信号,但是这两者技术要求差别不大

耶鲁公开课 - 生物医学工程探索课程节选

All right. We've got a big majority, and both are logical ways of thinking, but it turns out that the majority is correct, which is not always the case, but the electron is not ejected in this case.

好，大多数人都这么认为，这两种看法都是合乎逻辑的，但结果是大多数人是对的，这种情况不经常发生，但是电子在这种情况下,确实不会被逐出。

麻省理工公开课 - 化学原理课程节选

It's pretty arbitrary, but it's big relative to what the numbers were we were talking about before.

它是任意的，但它是跟数字是相关的,我们之前讲到过。

哈佛公开课 - 计算机科学课程节选

Trumpet, yeah, and he had this wonderful rich sound but boy, it was a big, huge sound, kind of the ultimate in-your-face trumpet player.

小号,是的,而且他让这声音听起来美妙而饱满,但是孩子们,这可是很大很响的声音,好像在你眼前演奏的一样

耶鲁公开课 - 聆听音乐课程节选

But you can imagine the inability to do that in a big population study with thousands and thousands of subjects, so we have to rely on data like this.

但你们可以想象在一个大样本研究中,不可能对数以千计的研究对象做这种培训,所以我们需要依靠像这样的数据

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

But you don't yet have these big state structures.

但你还没有见过这样的大国家结构

耶鲁公开课 - 欧洲文明课程节选

But let's quickly talk about the big three.

首先，我们快速地说说三大可变因素。

耶鲁公开课 - 心理学导论课程节选

So, that is something these writers share with modernism, but there is one big difference and I want to exemplify that for you just by reading to you two parallel texts, one from the modernist canon and one from the Beat canon.

所以，这就是这些作者和现代主义的相似之处，但其中有个很大的区别，我想通过举例来说明,我给你们读两段类似的文字，分别是标准的现代主义风格和垮掉的一代的风格。

耶鲁公开课 - 1945年后的美国小说课程节选

It's kind of unsettling because we like to know what things are, but at the same time it's not really a big problem because as long as we know about the fact that a certain notion of literature exists in certain communities we can begin to do very interesting work precisely with that idea.

可能会有点让人不安，因为我们总想知道事物的定义，但知不知道,实际上问题不大,只要我们知道在特定群体中对文学有特定的认识,我们就能在这种认识上做文章。

耶鲁公开课 - 文学理论导论课程节选

And you could build barricades across smaller streets, but not across big boulevards, and that was part of the rebuilding of Paris in the 1850s and '60s, more about that in a minute and much more about that later, because it's fascinating; at least, I think it's fascinating.

但街垒只适用于小巷,对于大路就不那么适用了,修街垒也算是巴黎十九世纪五六十年代重建的一部分,这个问题我们以后再谈,因为它引人入胜,至少我觉得如此

耶鲁公开课 - 1871年后的法国课程节选

But finally, Reiner says, well, thank you for visiting us, it's all very wonderful, but you know our audience would really like to know; it seems like a simple question but it's awfully hard to understand, but how can a great, big, enormous, heavy thing like this airplane get off the ground?

但最后 雷纳说到,谢谢你的来访,太棒了,但你知道吗,我们的观众非常想知道,这问题貌似简单,但却很难让人明白,问题是,像这么一个巨大且沉重的飞机,是如何飞起来的呢

耶鲁公开课 - 古希腊历史简介课程节选