Sometimes that subtle change can lead to a big change in the function of the protein.

有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化

耶鲁公开课 - 生物医学工程探索课程节选

As I mentioned earlier it would lead, of course, to big cycles of boom and bust.

正如我之前提到它的导致,当然,经济繁荣与萧条的大循环

耶鲁公开课 - 美国内战与重建课程节选