Mr.Ban said he has written to the G-20 members, outlining four areas where he thinks they must show leadership, including producing a "very substantial" international stimulus package in addition to their national ones, meeting their existing donor commitments and taking a firm stand against protectionism.

VOA: standard.2009.03.25

So, over the course of time this could have a very substantial impact on the community.

所以,这种病毒在一段时间内,会对当地社会产生持续的影响

耶鲁公开课 - 生物医学工程探索课程节选

There's some probability that it can get very, very close the nucleus, and that probability is actually substantial.

有一定的概率,它能非常非常接近原子核，这个概率是相当大的。

麻省理工公开课 - 化学原理课程节选