"That's really the biggest issue. When there is really a big sudden fire, the time to evacuate is extremely limited and extremely dangerous.

VOA: standard.2009.06.24

And so the big issue is -- this is what you must never do, but this is what you got to do if your phalanx is broken.

所以现在的大问题是,这也许是你在战场上永远不能做的事,但你在方阵被打散时不得不这么干

耶鲁公开课 - 古希腊历史简介课程节选

"You want to hold a review and you want to exclude the one big issue which should be right at the heart of that review."

VOA: standard.2010.04.30

U.S.officials hope it can be convened before key big-power discussions of the Iranian nuclear issue begin in New York during the third week of this month, on the sidelines of the U.N.General Assembly session.

VOA: standard.2009.09.11

The lack of housing is also a big issue,partly because of the years of conflict, which have not given us a clear idea of how many homes have actually been destroyed in Afghanistan or badly damaged.

VOA: standard.2009.09.13

"Obviously there is a bit of a spread between those two figures and it suggests the possibility of some political problems for the president if he should not take the military recommendation and that difference gets to be a big issue,".

VOA: standard.2009.10.09