Last week,researchers in the United States reported curing nine adults with sickle cell disease.

VOA: special.2009.12.16

Here the unique thing was that there's a restriction site inside that is present in normal DNA and not present in sickle DNA.

刚才例子中,特性就是在正常的基因中,有酶切位点,而在患者的基因中却没有

耶鲁公开课 - 生物医学工程探索课程节选

It's a single gene defect and we know exactly where the genetic defect is in sickle cell.

是一种单基因缺陷,而且我们准确地知道,镰状红细胞贫血的基因缺陷在哪里

耶鲁公开课 - 生物医学工程探索课程节选

Black people in Africa are the huge majority of those with sickle cell disease.

VOA: special.2009.12.16

How could I identify in a chromosomal DNA sample whether the sickle gene is present?

那我该怎么确定某染色体DNA样本中,是否存在这种致病基因呢

耶鲁公开课 - 生物医学工程探索课程节选

In a normal cell DNA that DNA in the normal cell - this DNA gets cut by the restriction enzyme, so the sickle gene ends up - so that hemoglobin gene ends up in two pieces.

一个正常细胞的DNA,正常细胞里的DNA,会被限制酶所剪切,因此镰状血红蛋白基因--,不对,是正常血红蛋白基因被切成两段

耶鲁公开课 - 生物医学工程探索课程节选