He is a leader in the sign-making industry - a real big gun,if you know what I mean.

VOA: special.2010.11.28

Well, I kind of ignored the notion of bias 0 by making it 0, so let's give it a big bias here.

我一开始的时候,是让偏向值等于，所以这次让我们设一个比较大的偏向值。

麻省理工公开课 - 计算机科学及编程导论课程节选

That's the big negativity in United States. The United States is making a huge mistake

这恰恰是美国的消极面了。美国正在犯一个大错误。

美国偶像 - SpeakingMax英语口语达人

Chocolate making is a big business.

VOA: special.2010.02.17

In any case, I thought I'd begin today by making a few remarks about the title of our course because it has some big words in it "theory" and "literature,"but also "introduction."

我想先,谈谈这门课的名称,因为里面有几个大词：,理论，文学和介绍“

耶鲁公开课 - 文学理论导论课程节选

Today, paper-making is a big business.

VOA: special.2009.01.26

Can you read this in the back? Am I making that big enough?

后面的同学看得清吗，我写得够大吗？

耶鲁公开课 - 金融市场课程节选

Today,paper-making is a big business.

VOA: special.2009.07.06

In fact, we'll talk about that concept throughout the course because one of the big challenges of making these sort of new biological therapies work in people to treat diseases is getting the right molecules into the right cells, at the right period of time.

实际上,我们会讲到一个,贯穿这门课程的概念,因为为了治疗疾病,而采用的新型生物学疗法,所面临的一个大问题就是,如何将正确的分子在适当的时候,转进正确的细胞当中

耶鲁公开课 - 生物医学工程探索课程节选

Indeed. Are you saying that this could be used as a formula for making some big profits in the market?

VOA: standard.2010.08.05

I'm just going to be paying back my debts and go bankrupt, so I'll take a big gamble and then at least I have a one in three chance of making money.

那样我就会因为要还债而破产,所以我要赌一把,至少有三分之一的机会能赢钱

耶鲁公开课 - 金融市场课程节选

As the love interest, Alex O'Loughlin joins a growing legion of hunky stars from Australia making it big on American screens.

VOA: standard.2010.04.30

So for a company that is just launching, or launching a new product line, or is making a big company shift, the Super Bowl offers a unique platform."

VOA: standard.2010.01.27