This is a big change from earlier models where NASA led and controlled the development of space vehicles.

VOA: special.2010.04.28

Sometimes that subtle change can lead to a big change in the function of the protein.

有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化

耶鲁公开课 - 生物医学工程探索课程节选

and go back to change the laundry over and pick it up, and it's really a big pain. It's really awful.

然后走回去把衣服拿出来，真是太痛苦了，真的很烦人。

与众不同的纽约 - SpeakingMax英语口语达人

A big change came four years ago, when Russia's new forestry law essentially privatized management of state forests.

VOA: standard.2010.08.10

It's a big change in some of these very poor villages to get a cow.

奶牛对这些赤贫的村庄来说可是生财之道

耶鲁公开课 - 金融市场课程节选

"It's a big deal. How big a deal you have to measure piece by piece but clearly it is the first major change in our health care system since nineteen sixty-five so that's a long time coming."

VOA: special.2010.03.27

So that's a big help. And equilibrium happens when there isn't any possible change of state that would satisfy this.

这个非常方便，当所有的变化,都无法满足这个公式的时候,系统就达到了平衡。

麻省理工公开课 - 热力学与动力学课程节选

That created a big constituency in favor of a dumb change. There was little warning.

这造就了一种悄无声息的变化,没有人提出警告。

斯坦福公开课 - 经济学课程节选

Changing the diet of populations is a pretty good idea and it's the kind of thing that could help individuals certainly lead healthier, happier lives, but also could change things like healthcare costs for a whole country, so these are big, big factors.

改变大众的饮食是个很好的想法,它不仅可以让人们过上更健康幸福的生活,还可以改变整个国家的医保费用,所以饮食是个非常非常重要的因素

耶鲁公开课 - 关于食物的心理学、生物学和政治学课程节选

so it's like a very big change.

因为这意味着一个巨大的变化。

洛杉矶和纽约不一样 - SpeakingMax英语口语达人

The financial situation is not as bad as it was in the 1930s but it's getting bad and as a result we're starting to see proposals for big change.

现在的金融衍生工具已经不像当年那么拙劣了,但是它却开始走下坡路,所以最后的结果是,我们不得不准备着新的变革。

耶鲁公开课 - 金融市场课程节选