This is a big change from earlier models where NASA led and controlled the development of space vehicles.
VOA: special.2010.04.28
Sometimes that subtle change can lead to a big change in the function of the protein.
有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化
and go back to change the laundry over and pick it up, and it's really a big pain. It's really awful.
然后走回去把衣服拿出来,真是太痛苦了,真的很烦人。
A big change came four years ago, when Russia's new forestry law essentially privatized management of state forests.
VOA: standard.2010.08.10
It's a big change in some of these very poor villages to get a cow.
奶牛对这些赤贫的村庄来说可是生财之道
"It's a big deal. How big a deal you have to measure piece by piece but clearly it is the first major change in our health care system since nineteen sixty-five so that's a long time coming."
VOA: special.2010.03.27
So that's a big help. And equilibrium happens when there isn't any possible change of state that would satisfy this.
这个非常方便,当所有的变化,都无法满足这个公式的时候,系统就达到了平衡。
That created a big constituency in favor of a dumb change. There was little warning.
这造就了一种悄无声息的变化,没有人提出警告。
Changing the diet of populations is a pretty good idea and it's the kind of thing that could help individuals certainly lead healthier, happier lives, but also could change things like healthcare costs for a whole country, so these are big, big factors.
改变大众的饮食是个很好的想法,它不仅可以让人们过上更健康幸福的生活,还可以改变整个国家的医保费用,所以饮食是个非常非常重要的因素
so it's like a very big change.
因为这意味着一个巨大的变化。
The financial situation is not as bad as it was in the 1930s but it's getting bad and as a result we're starting to see proposals for big change.
现在的金融衍生工具已经不像当年那么拙劣了,但是它却开始走下坡路,所以最后的结果是,我们不得不准备着新的变革。
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