That's a big change from the previous generation.

与上一代相比，这是一个巨大的变化。

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It was a big change in lifestyle when we moved to the country.

我们迁居到乡下，这在生活方式上是个巨大的变化。

《牛津词典》

The researchers noted a big change in the list of countries with the lowest adult mortality over the past forty years.

VOA: special.2010.05.05

Sometimes that subtle change can lead to a big change in the function of the protein.

有时候,蛋白质在结构上的小小改变,会导致其功能发生巨大变化

耶鲁公开课 - 生物医学工程探索课程节选

It's a big change in some of these very poor villages to get a cow.

奶牛对这些赤贫的村庄来说可是生财之道

耶鲁公开课 - 金融市场课程节选

But I just assumed that there was a big change that had taken place.

NPR: Role of U.S. Changing in New World Order

"It was a big change for the family and happened very quickly, " said Dean Sullivan.

BBC: Brookside star directs Wilfred Owen musical drama

That's a big change from a decade ago, when this generation was starting out on tour.

WSJ: French Open 2012: The Year Tennis Skewed Old