• Unlike phytochromes and phototropins, cryptochromes are not kinases.

    与植物色素和光蛋白不同,隐色素不是激酶。

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  • It functions in stoichiometric relationships forming heterotrimeric complexes with cycling and cyclin-dependent kinases.

    其功能与周期蛋白和周期蛋白依赖性激酶形成的异源三聚体存在化学计量关系。

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  • If one is really, for instance, captivated by the biochemistry of protein kinases, you don't necessarily have to work on kinases in oncogenesis.

    比如说,如果你真正着迷于蛋白激酶生物化学,你不一定要在肿瘤学范围内研究激酶。

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  • And several attempts to carve a new target from a family of enzymes called p38 kinases have also failed, despite favourable results in animal models.

    而且多次从酶家族P38激酶中寻求新目标的尝试也失败了,尽管动物试验的结果比较积极。

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  • The largest group of this family is the protein kinases.

    该家族的最主要成员是蛋白激酶。

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  • Tyrosine kinases are involved in the pathogenesis of most cancers.

    酪氨酸激酶参与大多数癌症的发病机制。

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  • Protein kinases and phosphatases play a central role in cellular signaling.

    蛋白激酶与蛋白磷酸酶在细胞信号传递中起着重要作用。

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  • BCRABL; tyrosine kinases; inhibitors; chronic myelogenous leukemia; review.

    bcrabl;酪氨酸激酶;抑制剂;慢性粒细胞白血病;综述。

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  • Inhibiting BCR-ABL tyrosine kinases can impede the growing progress of tumors.

    抑制BCR - ABL酪氨酸激酶可有效抑制肿瘤生长。

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  • These are known to be preferred sites for phosphorylation by ATM/ATR kinases (4,5).

    这些地方是已知的ATM/ATR激酶磷酸化的首选作用位点(4,5)。

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  • We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.

    我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化。

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  • This paper introduces the first, second and some new BCR-ABL tyrosine kinases inhibitors.

    本文介绍了第一、二代以及新近开发的BCR - ABL酪氨酸激酶抑制剂。

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  • Of the top nine kinases the software picked, seven have subsequently been shown to activate p53.

    由假设软件挑出的,排名前9位的激酶中,有7种后来被证明可以激活p 53。

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  • The largest group of kinases are protein kinases, which act on and modify the activity of specific proteins.

    蛋白激酶是数量最多的一类激酶,作用和修饰特定蛋白的活性。

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  • Chk2 is the mammalian orthologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases (1-3).

    Chk2是哺乳动物中和芽殖酵母Rad53和裂殖酵母Cds1检验点激酶同源的蛋白(1-3)。

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  • Many centrosome-related proteins and kinases have been found to regulate different steps of centrosome duplication.

    现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶,调控着中心体复制的各个步骤。

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  • Objective To study the effects of transfection of tyrosine kinases on the tumorigenesis of nasopharyngeal carcinoma.

    目的:研究酪氨酸激酶转染对鼻咽癌细胞成瘤的影响。

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  • Signalling cascades consisting of protein kinases play important roles in hormone signal transduction pathways of plants.

    蛋白质激酶的磷酸化级联放大系统在激素的信号转导中起重要作用。

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  • So far, 518 different kinases have been identified in humans and up to 30% of human proteins are modified by these kinases.

    到目前为止,已经在人体中发现了518种激酶,高达30%的人体蛋白质都是由这些激酶调节的。

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  • Receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCR) and ion channel receptors are main cell surface receptors.

    酪氨酸激酶型受体、G蛋白偶联受体和离子通道型受体是细胞表面三类主要受体。

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  • Histidine kinases are widely existed in higher plants and are important components of two-component signal transduction systems.

    组氨酸激酶在高等植物中广泛存在,是双组分信号系统的重要元件。

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  • They used the software to read the abstracts of 186,879 papers and produced a list of the most promising kinases for experiments.

    他们通过这种软件读取了186,879份论文的摘要,生成了一个最有希望用于试验的激酶目录单。

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  • The present invention relates to compounds of formula (I) useful as inhibitors of protein kinases, particularly of JAK family kinases.

    本发明涉及可用作蛋白激酶、特别是JAK家族激酶的抑制剂的式(i)化合物。

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  • Protein kinases play important roles in plant growth and development, hormone response as well as in response to abiotic and biotic stress.

    蛋白激酶在植物生长、激素调节和生物与非生物逆境胁迫反应中起着重要的作用。

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  • The result showed that 61 histidine kinases were found in the genome and 30 histidine kinases contained total conserved transmitter domain.

    结果表明:阿维链霉菌中存在61个组氨酸蛋白激酶,其中30个组氨酸蛋白激酶包含了全部的保守传递器结构域。

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  • However, further studies have indicated that they are actually DNA-damage-response kinases, regulating more than just cell-cycle checkpoints.

    进一步的研究表明它们事实上是DNA损伤-应答激酶,不仅仅是调控细胞周期的检查点。

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  • To investigate the expression and activation of mitogen-activated protein kinases in non-small cell lung cancer and its clinical significance.

    目的:探讨丝裂原活化蛋白激酶在非小细胞肺癌中的表达及其临床意义。

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  • Such lists can be projected onto prior knowledge of kinase-substrate interactions to infer the list of kinases associated with a specific protein list.

    这些列表能够被投射到激酶-底物相互作用的先验知识,以推断与一个特定蛋白质列表相关的激酶列表。

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  • Nur77 is heavily phosphorylated by multiple kinases, which may affect its transactivation activity as well as its subcellular localization (4, 10, 11).

    Nur77很大程度上是由多种激酶磷酸化,从而可能影响其转录活性以及其亚细胞定位(4,10,11)。

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  • Nur77 is heavily phosphorylated by multiple kinases, which may affect its transactivation activity as well as its subcellular localization (4, 10, 11).

    Nur77很大程度上是由多种激酶磷酸化,从而可能影响其转录活性以及其亚细胞定位(4,10,11)。

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