We found that pancreatic cancers contain an average of 63 genetic alterations, the majority of which are point mutations.
我们发现胰腺癌平均含有63个基因的改变，大多数为点突变。
Objective To detect genetic alterations in pleomorphic xanthoastrocytoma (PXA), and to investigate the mechanism of development of this neoplasm.
目的研究多形性黄色星形细胞瘤（PXA）的遗传学异常，以探讨该肿瘤的发病机制。
Scientists know that UV light can cause genetic alterations that prevent DNA from replicating properly, and these mutations can lead to diseases such as cancer.
科学家认为紫外光能导致基因改变阻止DNA正常复制并且形成突变导致疾病例如癌症。
There are multiple genes especially oncogenes and tumor suppressor genes involved in 'the genetic alterations which regulating the growth and differentiation of cells.
肿瘤形成与控制细胞生长和分化的多种基因特别是癌基因、抑癌基因的遗传改变有关。
It was a long shot, he said, but the technique identified 49 regions of the human genome that experienced a significant increase in genetic alterations, relative to chimpanzees.
长远来看，他说，但在遗传学变化中，已经通过技术鉴定，发现比较黑猩猩，人类基因组在49个区域有明显增加。
Although tumours are initiated synchronously by defined genetic alterations, only a subset becomes malignant, indicating that disease progression requires additional alterations.
虽然已知特定基因的变异可诱发肿瘤，但其中仅有部分可发生癌变，这表明疾病的进展尚需进一步的基因改变。
In these tumours with an altered control of genomic stability, accumulation of chemotherapy-induced genetic alterations may contribute to cell death and account for complete response.
在这些基因组稳定性控制发生改变的肿瘤中，化疗诱导的基因改变的累积可能会导致细胞死亡和解释对化疗产生完全反应。
These results extend the landscape of genetic alterations in leukaemia, and identify mutations targeting transcriptional and epigenetic regulation as a mechanism of resistance in ALL.
这些结果扩展了白血病的基因变异谱，确定后天调控与转录靶向突变为ALL的耐药机制。
Effects repeatedly found included reduced head size, genetic alterations in the central nervous system, increase in the death of cells that help form the skull, and deformed cartilage.
不断发现的影响还包括头小；中央神经系统基因改变；有助于构成头盖骨的细胞的死亡率提高；以及畸形软骨。
The researchers plan to further investigate the entire process of red blood cell formation, which may lead to insights about genetic alterations that underlie certain red blood cell disorders.
研究人员计划进一步研究整个细胞形成的过程，从而有要能发现某些红细胞异常疾病的基因改变机制。
This research is of particular importance, as recent data suggest that a large number of genetic alterations affect only a few major signaling pathways and processes involved in pancreatic tumor.
最近有资料显示在涉及胰腺肿瘤一些主要信号传导通路中存在大量的基因变异。
We now know from genetic studies that small alterations in the regulation of genes can have major anatomical consequences in a short amount of time.
通过遗传研究我们已经知道，基因调控方式的微小变更会在短时间内导致解剖学上的重大改变。
There are other examples of success in specifically targeting genetic changes in never-smokers with lung cancer, such as treatments of tumors with alterations in the EML4-ALK gene.
针对不吸烟者的基因改变进行靶向治疗，这有些其它的成功例子，比如针对有EML4-ALK基因改变的肿瘤进行的治疗。
The EWG added that exposure can also cause epigenetic changes, meaning alterations in the way genes switch off and on and genetic changes that can be passed on to the next generation.
EWG补充说暴露在PBA下还会导致遗传性变异，意味则各种基因的变异能够遗传到一下代身上。
It's not clear how permanent these genetic changes are, but previous data suggests that, at least in smokers, some of the alterations may be irreversible.
我们不清楚这些基因变化会维持多久，但是先前的数据显示，至少是在吸烟者的基因中，有些变化已经是不可复原的了。
Genetic damage with DNA alterations leads to point mutations of genes, translocations of genetic material between chromosomes, and gene reduplication with amplification.
伴随DNA改变的基因损伤会导致基因的点突变、染色体间基因移位和扩增性基因复制。
Essential hypertension (EH), a complex polygenic disease, is considered to the result of the genetic interaction of multiple gene alterations in concert with environmental factors.
原发性高血压是一种复杂的多基因疾病，被认为是多个变异了的基因遗传交互以及环境因素共同作用的结果。
The genetic changes during or subsequent to introduction have led to alterations in its population biology and behavioral genetics; these, in turn, have promoted the invasive success of RIFA.
该类害虫在入侵时以及入侵后在种群生物学和行为遗传学上发生了一系列的变异，使其成为一种入侵成功的外来生物。
Alterations in the neurotrophic levels either due to age, genetic background or other factors might contribute to neurodegeneration.
由年龄、基因突变或其他因素导致的神经营养因子水平的改变可以导致神经元退行性变。
Alterations in the neurotrophic levels either due to age, genetic background or other factors might contribute to neurodegeneration.
由年龄、基因突变或其他因素导致的神经营养因子水平的改变可以导致神经元退行性变。
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