Targeting genetic alterations can provide a basis for Specificity, but cannot generally provide Comprehensiveness.

FORBES: Cancer's New Era Of Promise And Chaos

Drug resistance and disease progression have been observed all for anticancer drugs that target specific genetic alterations.

FORBES: Cancer's New Era Of Promise And Chaos

But for 1% who carry a significant number of genetic alterations, the risk rises to one in two.

BBC: DNA test reveals 80 markers for inherited cancer risk

Given the billions of cancer cells in a patient, some cells will likely evolve that lack the targeted genetic alterations or that are resistant to the targeted therapy.

FORBES: Cancer's New Era Of Promise And Chaos

It plans to cull these variations to find particular mutations that predispose patients to major killers and also to genetic alterations that increase the risk of side effects from prescription drugs.

FORBES: Technology

It plans to cull these variations to find patterns of particular mutations that predispose patients to major killers such as heart failure, as well as genetic alterations that increase the risk of side effects from prescription drugs.

FORBES: Magazine Article

Furthermore, every cancer cell in a patient is also generally unique with thousands of unique genetic and epigenetic alterations.

FORBES: Cancer's New Era Of Promise And Chaos

The evolutionary nature of cancer implies, contrary to conventional wisdom, that the essential features of any therapy for the consistent cure or control of cancer must be independent of the particular pathways of tumor cell evolution, and independent of any particular genetic or epigenetic alterations.

FORBES: Cancer's New Era Of Promise And Chaos