MRP protein expression and intracellular accumulation of DNR were assayed with flow cytometry.
流式细胞仪检测MRP蛋白表达和细胞内柔红霉素积累量。
Firstly, analyze the primary Dynamic noise reduction (DNR) model, and present an improvement project.
分析原动态降噪(DNR)模型并提出改进方案。
Both DNR accumulation reduced and DNR efflux increased in four MDR cell lines as compared with their parental cell lines.
四株mdr细胞系与其相应敏感细胞系相比，前者对DNR的摄取均减少，外排均增加。
Conclusions: FCM is a good method to detect MDR protein and MRP function of bladder carcinoma, and DNR is a good probe to detect MRP function by FCM.
结论：FCM是检测膀胱癌多药耐受蛋白质表达水平和MRP功能水平的好方法，DNR是FCM检测MRP功能的良好探针。
Objective:To study the correlation between cytotoxicity of daunorubicine (DNR) and harringtonine (H) to leukemic cells in vitro from 39 patients with acute myeloblastic leukemia (AML).
目的：化疗药物对急性髓性白血病细胞体外毒性进行相关性研究。
Conclusion Altered subcellular distribution of DNR in resistant cell line was related to MDR gene formation. Quercetin could inhibit MRP1 function and could restore the subcellular DNR distribution.
结论DNR在耐药细胞中的异常分布与肿瘤细胞耐药基因形成有关，槲皮素在体外直接抑制MRP1功能，恢复DNR在细胞内的分布。
Conclusion Altered subcellular distribution of DNR in resistant cell line was related to MDR gene formation. Quercetin could inhibit MRP1 function and could restore the subcellular DNR distribution.
结论DNR在耐药细胞中的异常分布与肿瘤细胞耐药基因形成有关，槲皮素在体外直接抑制MRP1功能，恢复DNR在细胞内的分布。
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