A few drugs have harmful effects when used together and should not be combined (an example is stavudine and zidovudine).
某药物一起使用时的会产生有害影响，不应组合使用(例如司他夫定和齐多夫定)。
Zidovudine may competitively inhibit the intracellular phosphorylation of stavudine. Therefore, use of zidovudine in combination with Stavudine is not recommended.
齐多夫定会竞争性抑制司他夫定的磷酸酰化，因此禁止与齐多夫定联合用药。
The stavudine was prepared from 5-methyluridine via six steps in 34% overall yield, in which the key step is the selective acylation of 5-methyluridine by propionyl chloride.
该路线以5-甲基尿苷为起始原料，关键步骤是5-甲基尿苷和丙酰氯的选择性酰化反应，六步反应总收率为34%。
The stavudine was prepared from 5-methyluridine via six steps in 34% overall yield, in which the key step is the selective acylation of 5-methyluridine by propionyl chloride.
该路线以5-甲基尿苷为起始原料，关键步骤是5-甲基尿苷和丙酰氯的选择性酰化反应，六步反应总收率为34%。
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