Several studies have explored the role of S1P in the pathogenesis of RA.
已有几项研究阐述了1-磷酸鞘氨醇在类风湿关节炎发病中所起的作用。
HGF stimulation could increase the activity of SPK and cellular S1P in ECV304 cells.
肝细胞生长因子(HGF)刺激能增强ECV304细胞SPK的活性和细胞内s1p水平。
The combined tumorigenic and angiogenic effects of S1P make it an excellent target for anticancer therapy.
其致瘤和促血管生成的双重作用使得S1P成为一个作为抗癌治疗非常好的靶点。
It is difficult to find an area of physiology and pathophysiology in which S1P does not have important if not key roles.
很难发现生理学和病理生理学领域中S1P不起重要作用，即使不是关键作用。
Sphingosine kinase (SPK) is a key enzyme catalyzing the formation of sphingosine 1 phosphate (S1P), which is a lipid messenger with strong angiogenic activity.
细胞内鞘氨醇激酶（SPK）是催化鞘氨醇生成1-磷酸鞘氨醇（S1P）的限速酶。
The aim of this article was to review the biology and distribution of S1P, together with its role in ra, and to discuss its potential as a therapeutic target for ra.
本文写作目的主要是复习1 -磷酸鞘氨醇的生物学特性和分布，及其在类风湿关节炎发病中的作用，进而讨论它作为类风湿关节炎治疗靶点的可能性。
S1P improves the increase in the microvessel permeability caused by PAF, which might be mediated by strengthening adherent junction and inhibiting the formation of endothelial gaps.
S1P能改善PAF引起的血管通透性增高，其作用与加强内皮细胞间粘附连接，抑制细胞间隙打开有关。
Objective To investigate the effect and mechanism of sphingosine 1-phosphate (S1P) on action potential (AP) and voltage-dependent potassium current (KV) in isolated guinea pig ventricular myocytes.
目的研究1 -磷酸鞘氨醇(S1P)对豚鼠心室肌细胞动作电位(AP)及电压依赖性钾电流(KV)的作用及其机制。
Objective To investigate the effect and mechanism of sphingosine 1-phosphate (S1P) on action potential (AP) and voltage-dependent potassium current (KV) in isolated guinea pig ventricular myocytes.
目的研究1 -磷酸鞘氨醇(S1P)对豚鼠心室肌细胞动作电位(AP)及电压依赖性钾电流(KV)的作用及其机制。
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