"The advantage of a site-specific recombinase is that the enzyme does everything," says Stark, who is also investigating the potential of ZFRs in genetic engineering.
“位点专一重组酶的优势就是酶做了所有的事。”斯达克说，他同时还在调查研究Z FR在遗传工程学中的潜力。
When the intended gene, which would have been inserted at the same time, comes along, the recombinase recognises it, and binds the DNA to the ends, repairing the break (see diagram).
当预期的可同时植入的基因出现时，承认它的重组酶，会把它固定在DNA的两端，开始修补DNA(见图)。
As proof of principle, Barbas's team has taken human cells and inserted a gene that their ZFR would recognise. They then used the recombinase to insert the gene into the cells' genome.
巴尔·巴斯的团队为了证实这一原理，他们在人体细胞中植入了他们的ZFR能辨识的基因，然后利用重组酶将基因植入到基因组细胞中。
As proof of principle, Barbas's team has taken human cells and inserted a gene that their ZFR would recognise. They then used the recombinase to insert the gene into the cells' genome.
巴尔·巴斯的团队为了证实这一原理，他们在人体细胞中植入了他们的ZFR能辨识的基因，然后利用重组酶将基因植入到基因组细胞中。
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