Rapamycin is not perfect, however.
但是，雷帕霉素并不理想。
Rapamycin is known as a kind of macrolide antibiotics.
雷帕霉素是一种大环内酯类抗生素。
That is not to recommend people take doses of rapamycin.
这并不是推荐人们服用雷帕霉素。
When tested on nine-month-old mice, rapamycin had little effect.
对九个月大老鼠进行试验时，雷帕霉素作用甚微。
The drug, called rapamycin, was originally found in bacteria from Easter Island.
这种叫雷帕霉素的药最先是在复活节岛的一种细菌中找到的。
But the new study shows that rapamycin is still a useful tool for investigating aging.
但是新的研究表明雷帕霉素仍然是一个有效的研究衰老的工具。
Weimbs and his colleagues wondered about treating kidney patients with rapamycin.
威母波斯和他同事想知道瑞帕霉素是否能治疗肾脏病人。
Earlier human trials have shown, however, that rapamycin can have serious side effects.
但是，早些时候的人体试验显示，雷帕霉素有很严重的副作用。
Rapamycin is a bacterial product originally found in a soil sample from Easter Island.
雷帕霉素是一种最初发现于来自复活节岛土壤样本中细菌的制品。
Current basic research suggests that rapamycin may be a very effective treatment for epilepsy in TSC.
研究结果建议，雷帕霉素可能是TSC癫痫症的一种非常有效的治疗。
Rapamycin suppresses the immune system and carries strong warnings about the resulting risk of infections and death.
雷帕霉素会抑制免疫系统的活动，可能因此造成感染和死亡的风险，在这方面已经有过严重的前车之鉴。
Objective To explore the effect of rapamycin in treatment of refractory chronic graft-versus-host-disease(cGVHD).
目的探索雷帕霉素在慢性移植物抗宿主病治疗中的作用。
It's unclear whether these problems would counteract any longevity benefit that rapamycin might provide in humans.
尚不清楚，这些问题是否会抵制雷帕霉素可能提供延长生命的益处。
However, because rapamycin depresses the immune system, it would have serious side effects for people with Parkinson's.
即便如此，因为雷帕霉素抑制了免疫系统，它对帕金森症患者有负面作用。
Pharmaceutical companies would also be wise to hunt for drugs that act on the same biological pathway as rapamycin.
制药公司也会明智地去寻找与一些药物，这些药物作用与雷帕霉素所作用的生物途径相同。
Previous research on rapamycin has hinted that it may have the power to extend human lifespan by more than a decade.
以前对雷帕霉素的研究为其也许可以把人的寿命延长十几岁提供了线索。
Made by a type of soil bacterium, rapamycin has extended the life spans of yeast, flies and worms by about 25 percent.
雷帕霉素是用一种土壤细菌做成的，能将酵母、苍蝇和蠕虫的寿命延长约25%。
Healthy ageing will also be the metric by which medicines like rapamycin are tested against in humans, says Kaeberlein.
健康的变老将是一些用在人类身上试验的，类似雷帕霉素药物的尺度，Kaeberlein说到。
Objective To evaluate the clinic effect of CYPHERTM (rapamycin) stent in treatment of bifurcation coronary artery lesion.
目的评价雷帕霉素涂层支架在冠状动脉分叉病变中的临床疗效。
The fact that rapamycin is already clinically approved for other USES will facilitate future clinical trials of the drug.
实际上，瑞帕霉素已被批准临床用于其他用途，这将有助与将来该药地临床验证。
Mice on rapamycin, which was first discovered in soil fungus from Easter Island, lived about 10 per cent longer than other mice.
老鼠喂养的雷帕霉素，最开始是在复活岛上土壤中的真菌上发现的，这些吃雷帕霉素的老鼠比其他的老鼠生存的时间长10%。
Figure 1: a plaque on Easter Island commemorating the discovery of a bacterium producing rapamycin, a potent immunosuppressant.
图1：复活节岛上的铭牌，纪念一种能产生抗免疫物质——纳巴霉素的发现。
Rapamycin leaves users susceptible toinfection — at least in the doses typically used today — and has otherharmful side effects too.
至少在患者通常所用的剂量下，雷帕霉素非常容易令其受感染，并且它也有其他方面不好的副作用。
And some researchers say there would be serious concerns in testing rapamycin, or any drug, in healthy people just to slow aging.
有些研究者说，仅仅为了延缓衰老而在健康的人身上试验雷帕霉素或其他任何药物，都会引起严重担忧。
But the new finding by Strong and his colleagues "more clearly identifies the [target of rapamycin] pathway as important across species."
斯特朗及其同事最近发现，更多的人清楚认为雷帕霉素靶蛋白通道在各个物种间间重要性。
Suppression of target of rapamycin, a downstream effector of phosphoinositide 3-kinase, also prevented lipofuscin accumulation in the heart.
雷帕霉素作用点（即为磷酸肌醇-3激酶基因下游的受动器）的抑制也同样能够阻止脂褐质在心肌的积聚。
Rapamycin, the other big candidate, has one clear advantageover resveratrol: it's already FDA approved as a drug — but as animmunosuppressant.
雷帕霉素，另外一种抗衰老的重要健将，与白藜芦醇相比有一个非常明确的优点：雷帕霉素已经被美国食品药品管理局认可，但是是作为一种免疫抑制剂认可的。
Using the genetically engineered mice her lab developed, one preclinical study is already under way, testing an existing drug called Rapamycin.
应用她的实验室开发的一种基因工程小鼠，一种名为雷帕霉素的现有药物已经开始临床前研究。
Objective To investigate the effects of rapamycin on proliferation, levels of interleukin-2 (IL-2) and cell-cycle of mouse t lymphocytes in vitro.
目的研究雷帕霉素对小鼠t淋巴细胞体外的增殖、白细胞介素2 (IL - 2)表达及细胞周期的影响。
A commentary released with the rapamycin study strongly cautioned against taking the drug to prolong life because of potentially deadly side effects.
与雷帕霉素研究一起发布的一篇评论警告称，由于可能出现致命的副作用，不可服用雷帕霉素来延长寿命。
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