It is really tough to identify one big issue...
很难讲什么是最大的问题。
One big issue that Holtzman is concerned about is identity.
Holtzman担心的问题之一是身份问题。
There was one big issue for the site to build a house on: part of the site was being occasionally used as a passage for villagers.
在这块场地上建造一座住宅，有一个大的问题就是：场地的一部分偶尔会作为村民的交通道路来使用。
In the category of general problems with bytecode generation, I'd list one big issue: the need to make sure that the code you're generating is going to be valid according to the JVM specification.
在字节码生成的一般性问题方面，我列出了一个大问题：需要确保正在生成的代码符合JVM规范。
Switzerland has already chosen one version of this approach by forcing its two big banks to issue new contingent convertible (CoCo) bonds.
瑞士已经采取了类似的做法，规定其两家大银行发行新的或有可转换（CoCo）债券。
This is really the big issue. And one I really get.
这确实是个大问题，也是真正难倒我的问题。
One key issue: Mergers and acquisitions — the main drivers of big wealth — could die down with tighter credit.
一个关键问题是：作为创造巨富的主要推动力的并购交易可能会因信贷紧缩而减少。
Keep the tool simple and let it do one job well. With lack of support for test maintenance, it really becomes a big issue for QAs to use this tool effectively.
没有了对测试维护的支持，QA有效地使用它确实成了大问题。
But figuring out what to do with the nuclear fuel they generate is a big issue - and one that hasn't been resolved for decades.
但是，搞清楚如何处理用过的核燃料是一个大问题，也是一个几十年来没有得到很好解决的问题。
That's a big issue. You can fix one thing, you break something else.
你可以解决一个问题，但你破坏了其它的程序。
But the more pressing issue - and the hidden one that most big-time pundits don't write about - is how messed up Congress has become.
但更为紧迫的是，国会早已变得一团糟；可那些声名斐然的学者是不会提及这个潜藏事实的。
One important issue to note: When I tried the big-RDF-database approach to such a synonym-driven search four years ago, I had a lot of trouble with performance.
有一点要注意，四年前我尝试用大型 RDF 数据库进行这种同义词驱动的搜索时遇到了很多性能问题。
One other really big issue is that unless you embed your scripts in the body of a document you’ll have to start them when the document has finished loading.
另一个棘手的问题是，嵌入在页面头元素的脚本，必要要等页面加载完成后才能被调用。
That image is the near future image of you, the person who has solved that big issue of changing negative compulsion to a positive one.
这图像是你很近的未来图像，那个你已经解决了一个大问题，将消极的冲动转化为积极的冲动。
Switzerland has already chosen one version of this approach by forcing its two big Banks to issue new contingent convertible (" CoCo ") bonds that turn into equity if necessary.
瑞士已经采取了类似的做法，规定其最大的两家银行发行新的或有可转换(CoCo)债券，能够在必要时转换为股权。
Give everyone CARDS and ask them to identify the factors that affect the issue or problem, writing one idea per card (big enough so that they are easy to read).
给每个人一个卡片和问他们识别对争论和问题的的影响因素，在每个卡片上写上一个构思(足够大的卡片方便他们阅读)。
Overall this was not a big issue, but one that needed to be dealt with nevertheless.
全部地这不是一个大的议题、但是需要被处理的一个然而。
The housing issue in big cities involves many aspects. I do hope in the near future, no one needs to worry about his or her housing problem.
大城市的居住问题，涉及到很多方面，希望在不久的将来，人人都不用担心住房问题。
This is such a big issue, and I think the work Ma Jun and others are doing will bring environmental pollution in China to the forefront as one of the biggest global problems of our time.
把中国环境污染这个问题提到讨论的日程上，让人们了解到这是现代世界最严重的问题之一。
Wang Han: One of the things that's a big issue in China has to do with the education system and creativity.
王汉：在中国一个重要的话题是教育制度和创造性。
Wang Han: One of the things that's a big issue in China has to do with the education system and creativity.
王汉：在中国一个重要的话题是教育制度和创造性。
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