It is really tough to identify one big issue...

很难讲什么是最大的问题。

youdao

One big issue that Holtzman is concerned about is identity.

Holtzman担心的问题之一是身份问题。

youdao

There was one big issue for the site to build a house on: part of the site was being occasionally used as a passage for villagers.

在这块场地上建造一座住宅，有一个大的问题就是：场地的一部分偶尔会作为村民的交通道路来使用。

youdao

"You want to hold a review and you want to exclude the one big issue which should be right at the heart of that review."

VOA: standard.2010.04.30

There's never been a successful third-party political culture take hold in this country without one really big issue to drive it.

美国就从没有过,第三政党真正成功执政的时候,因为缺乏一个真正重大的议题来支持它

耶鲁公开课 - 美国内战与重建课程节选

That's a big issue. You can fix one thing, you break something else.

你可以解决一个问题，但你破坏了其它的程序。

麻省理工公开课 - 计算机科学及编程导论课程节选

One big issue will be transporting the runners to the starting line on Staten Island.

WSJ: New York City Marathon Still Set for Sunday: Mayor Bloomberg

Looking more deeply at the out-migration and its message, one big issue is clearly jobs.

FORBES: Move up http://i.forbesimg.com t Move down

One big issue among electric-vehicle drivers is how and where to re-charge their cars or trucks.

FORBES: Electric-Car Charging Stations Will Be The Next Important Issue for Electric-Powered Vehicles