RNA synthesis can proceed through nucleosomes.
RNA的合成在核小体上进行。
Nucleosomes; Lung cancer; Chemotherapy; Prediction; Monitoring.
核小体；肺癌；化疗；预测；监测。
As the genetic blueprint of life, DNA must be deciphered or "read," even when densely packed into nucleosomes.
DNA作为生命的遗传蓝图，必须被解码或被“阅读”，甚至在被紧密“打包”放进核小体的时候也是如此。
Solenoid --- A fiber composed of compacted strings of nucleosomes, forming the fundamental unit of chromatin organization.
核小体串珠压缩整合而成的一种纤维结构，形成染色质结构的功能单位。
Luger and her colleagues next packaged the modified histones they received from Shokat's group into recombinant nucleosomes and chromatin.
Luger和他的同事随即包装了从Shokat小组得来的修饰过的组蛋白，形成核小体和染色质的重组体。
The researchers began their work with the goal of learning how two different methylation marks affect the overall structure of nucleosomes and chromatin.
研究人员怀着了解两种不同的甲基化标记怎样影响核小体和染色质结构的目的开始工作。
Nucleosomes are grape-like structures formed by strands of DNA wrapped like vines around histone proteins, and serve to organize enormously long DNA molecules.
核小体有着葡萄状结构，由葡萄藤样的DNA链环绕组蛋白所形成，其作用是组织极长的DNA分子。
With this new set of tools, Luger and her colleagues did X-ray crystallographic and biophysical studies to see how methylation affects the structure of chromatin and nucleosomes.
利用这种新型工具，Luger和他的同事进行了X射线晶体学和生物物理学研究，来看甲基化怎样影响染色质和核小体结构。
But the interesting question will be whether their dynamics change with methylation-whether individual nucleosomes may have a higher propensity to unfold, to unravel slightly or just to be remodeled.
但是有趣的问题是它们是否随着甲基化发生动态变化——个体核小体是否有会有更大的倾向来解开，拆开染色质，还是仅仅被改型。
But the interesting question will be whether their dynamics change with methylation-whether individual nucleosomes may have a higher propensity to unfold, to unravel slightly or just to be remodeled.
但是有趣的问题是它们是否随着甲基化发生动态变化——个体核小体是否有会有更大的倾向来解开，拆开染色质，还是仅仅被改型。
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