• HDAC inhibitors block the removal of these acetyl groups.

    HDAC抑制剂阻断乙酰基化过程。

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  • We found that the HDAC inhibitors drastically improved the learning ability of our mouse model.

    我们发现HDAC抑制剂大大提高了小白鼠学习能力

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  • The object is to find a novel pharmacological activity of a compound capable of inhibiting an HDAC.

    本发明目的在于发现具有HDAC抑制作用化合物的新的药 理作用

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  • The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC).

    发明涉及作为组蛋白乙酰基酶(HDAC抑制剂异羟肟衍 生物。

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  • HDAC activity plays a key role in the regulation of gene expression, and HDAC is a clinically validated cancer target.

    HDAC活性基因表达调控发挥关键作用HDAC经过临床验证癌症靶标。

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  • However, existing HDAC inhibitors can exhibit low potency, lack of selectivity, and poor pharmacokinetic or toxicity profiles.

    现有HDAC抑制剂缺乏选择性药代动力学毒性特征较差

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  • HDAC inhibitors are a newer class of cancer drugs that can, as single agents or in combination with other anticancer agents, kill cancer cells.

    HDAC抑制剂一类较新的抗癌药,单用其他抗癌药联合使用时可杀死癌细胞

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  • In the new study published in the journal cancer Prevention Research, the intake of sulforaphane did reduce HDAC activity, as well as cancer cell growth.

    这项刊登预防癌症研究刊物中的研究结果也指出,女性摄取萝卜硫后,不但癌细胞增长减缓,就连组蛋白脱乙酰酶活性也降低。

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  • Aim to investigate the cytotoxic activity of HDAC inhibitor Trichostatin a (TSA) combined with anticancer drugs targeting DNA on T24 bladder cancer cell line.

    目的观察h dac抑制剂曲古霉素a (TSA)针对DNA抗癌药物联用膀胱癌t 24细胞的杀伤作用。

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  • This review focused on the advances of the effect of feed additives, such as butyrate and plant extracts, on model animal and livestock as inhibitors of histone deacetylases (HDAC).

    本文综述丁酸植物提取物饲料添加剂作为蛋白去乙酰化酶(HDAC)抑制剂模型动物畜禽上研究进展

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  • The preclinical efficacy and pharmacokinetic properties of HBI-8000 may translate into an improved clinical profile over other HDAC inhibitors currently being marketed or in development.

    HBI- 8000临床有效性药代动力学特性预示,其临床特性可能优于目前市售开发中的其他HDAC抑制剂

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  • HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.

    组蛋白脱乙酰基酶蛋白乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控影响特定基因表达,改变细胞周期的进程。

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  • HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.

    组蛋白脱乙酰基酶蛋白乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控影响特定基因表达,改变细胞周期的进程。

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