We found that the HDAC inhibitors drastically improved the learning ability of our mouse model.
我们发现，HDAC抑制剂大大提高了小白鼠的学习能力。
HDAC inhibitors block the removal of these acetyl groups.
HDAC抑制剂阻断了去乙酰基化过程。
The object is to find a novel pharmacological activity of a compound capable of inhibiting an HDAC.
本发明的目的在于发现具有HDAC抑制作用的化合物的新的药 理作用。
The present invention relates to hydroxamic acid derivatives that are inhibitors of histone deacetylase (HDAC).
本发明涉及作为组蛋白脱乙酰基酶（HDAC）抑制剂的异羟肟酸衍 生物。
HDAC activity plays a key role in the regulation of gene expression, and HDAC is a clinically validated cancer target.
HDAC活性在基因表达的调控中发挥关键作用，HDAC是一种经过临床验证的癌症靶标。
However, existing HDAC inhibitors can exhibit low potency, lack of selectivity, and poor pharmacokinetic or toxicity profiles.
但现有HDAC抑制剂效度低、缺乏选择性、药代动力学或毒性特征较差。
HDAC inhibitors are a newer class of cancer drugs that can, as single agents or in combination with other anticancer agents, kill cancer cells.
HDAC抑制剂是一类较新的抗癌药，单用或与其他抗癌药联合使用时可杀死癌细胞。
This review focused on the advances of the effect of feed additives, such as butyrate and plant extracts, on model animal and livestock as inhibitors of histone deacetylases (HDAC).
本文综述了丁酸和植物提取物等饲料添加剂作为组蛋白去乙酰化酶(HDAC)抑制剂在模型动物及畜禽上的研究进展。
The preclinical efficacy and pharmacokinetic properties of HBI-8000 may translate into an improved clinical profile over other HDAC inhibitors currently being marketed or in development.
HBI- 8000的临床前有效性和药代动力学特性预示，其临床特性可能优于目前市售或开发中的其他HDAC抑制剂。
HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。
HDAC and histone deacetylase inhibitors (HDI) can affect expression of some specific genes and induce cell differentiation growth arrest and apoptosis through regulating histone acetylation level.
组蛋白脱乙酰基酶与组蛋白脱乙酰基酶抑制剂通过对组蛋白乙酰化水平的调控，影响特定基因的表达，改变细胞周期的进程。
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