EGFR gene copy number alteration and mutation are highly variable and scientists have been challenged to define their prognostic significance in triple-negative breast cancer.
EGFR基因拷贝数的改变和突变有很大的差异，科学家试图定义其在三阴性乳腺癌中的预后意义。
Most people with only one copy of the gene—"carriers"—survive and pass the gene to offspring.
大多数只有一个基因拷贝的人——“携带者”——能够存活下来并将基因传给后代。
If a copy of a gene is a bit different from the original, that's called a genetic mutation.
如果一个复制的基因与原来的有些许不同，那就叫做基因突变。
So a gene usually cannot be passed on, unless it's an exact copy.
因此基因经常不能传递下去，除非是准确的复制。
A gene is a piece of biological information that gets copied or replicated, and the copy or replica is passed on to the new generation.
基因是一段被复制或重组的生物信息，这种复制或重组会传递给下一代。
To keep things straightforward, the researchers chose to work with mice who carried just one copy of the gene.
他们的方法单刀直入，研究人员选择研究只带了一个这种基因拷贝的老鼠。
So how a person's KLF14 gene may affect expression of other metabolism-related genes is dependent on the copy received from the mother.
因此，一个人的KLF14是否影响到新陈代谢相关的基因的活动取决于来自母亲的基因。
Around the same time, Fisher and his team engineered mice so that one copy of their FOXP2 gene carried the same mutation as that found in the KE family.
与此同时，费舍尔和他的团队也培养了在FOXP2基因中一种携带和KE家庭同样突变的老鼠。
To figure out how the genetic mutation impacts sleep, Fu and her colleagues genetically engineered mice to have either two copies of the mutant gene or just one copy.
为了去弄清楚基因是如何影响睡眠的，Fu和她的同事用基因工程的手段让老鼠携带2个拷贝的变异基因或者一个。
Surprisingly, electrophysiology studies of the family members found that people who carry only one copy of either defective gene may not develop CMT, but they are not free from nerve problems.
令人惊喜的是，针对Lupsik家族的电生理学研究表明，如果只携带有一个突变基因的话，或许可以避开CMT，然而他们也同样有神经问题。
In a study of nearly 3, 000 people, around 38% inherited one copy of the gene variant and were biologically three to four years older than those who did not carry the sequence.
对近三千人的研究显示，约有38%的人带有遗传性基因变体，与没有这一基因序列的人相比，他们的生物年龄要老三到四岁。
However, only a single copy of the gene is mutated in tumours, raising the possibility that the mutations do not result in a simple loss of function.
然而，在肿瘤中只有一个基因的单一复制出现突变，那就会增加突变的可能性而不仅仅是导致一个简单功能的丢失。
Because men have only one X chromosome that they inherit from their mother and thus only one copy of the TEX11 gene, any mutation could theoretically lead to sterility.
因为男性只有一条从母亲那里遗传来的X染色体，因此他们的TEX11基因只有一个拷贝，理论上来说，TEX11基因的任何突变都可以导致不育。
DEFB gene products are small antimicrobial proinflammatory peptides, and copy number variation (CNV) could reasonably influence susceptibility to infection and inflammation.
DEFB基因产物是小分子抗菌肽，且拷贝数变化(CNV)可显著影响易感性及炎症反应。
LOH is usually defined as the loss of normalfunction of one copy of a gene in which the other copy was already inactivated.
杂合性丢失是基因一个拷贝的正常功能丢失，同时另一个拷贝已经失活。
The child only needs to inherit one copy of the gene to have autism.
小孩只要遗传到一个复制的基因，就可能得自闭症。
These deletions or duplications, also called copy-number changes, can change the dosage of a gene.
这些缺失或者是重复，也被称做是拷贝数的改变，能改变一个基因的数目。
Transgenes should be with single copy and without accessory sequence, and with consistence to express and stable genetic in various transgenic plants in a new gene transformation program.
新的转化程序要求把基因导入农艺性状优良的品种中，呈单拷贝、不带有辅助序列，并在不同的转化体中表达一致，稳定遗传。
We determine the copy number oft -PA gene for the cell line.
测定工程细胞株基因拷贝数是细胞生物学特性鉴定的一个方面。
Clone copy operator, immune gene operator and clone selection operator were performed during the evolutionary.
在算法进化过程中，引入克隆复制算子、免疫基因算子、克隆选择算子。
Transgenes should be genes with single copy and without marker gene, and be able to express and stable inheritable in various transgenic plants in a new gene transformation program.
新的基因转化程序要求转基因为单拷贝，不带有标记基因，并在不同的转化体中表达一致，稳定遗传。
One copy of this gene leads to a 1.2kg (3lb) weight increase while those with two copies are, on average, 3kg (7lb) heavier.
这个基因的一个拷贝导致体重增加1.2kg，而两个拷贝使体重平均增加3kg。
A patient who has at least one good copy of the gene is much more likely to escape the disease or experience it in a relatively mild form.
一个病人有至少一种好的基因遗传，更有可能避免这种疾病或者遭遇此疾病时症状会比较轻微。
Conclusion With this method the desired multi-copy gene can be obtained that lays the foundation for highly effective expression.
结论该方法能方便高效地获得所需的多拷贝基因，为进一步进行高效表达打下基础。
Conclusion With this method the desired multi-copy gene can be obtained that lays the foundation for highly effective expression.
结论该方法能方便高效地获得所需的多拷贝基因，为进一步进行高效表达打下基础。
应用推荐